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• W2104548717 abstract "Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease.To compare serum selenium (s-Se) values in patients with newly diagnosed autoimmune thyroid disease and controls from the Danish population.S-Se was measured in triplicate by a fluorimetric method.Patients with newly diagnosed Graves' disease (GD) (n = 97) or autoimmune overt hypothyroidism (AIH) (n = 96), euthyroid subjects with high serum levels of thyroid peroxidase antibody (TPO-Ab) (TPO-Ab > 1500 U/ml, n = 92) and random controls (n = 830).Differences in s-Se values.S-Se was lower in patients with GD than in controls (mean (SD), GD: 89·9 μg/l (18·4); controls: 98·8 μg/l (19·7), P < 0·01). This was confirmed in a multivariate logistic regression model adjusting for age, sex, mineral supplements, smoking, geographical region and time of sampling (P < 0·01). In a linear model, s-Se was similar in patients with AIH (mean (SD): 98·4 μg/l (24·9)) and in controls (P = 0·86). In the multivariate model however, s-Se was marginally lower in patients with AIH compared to controls (P = 0·04). There was no significant difference in s-Se between euthyroid participants with high TPO-Ab and random controls (linear: P = 0·97; multivariate: P = 0·27).Patients with newly diagnosed GD and AIH had significantly lower s-Se compared with random controls. Our observation supports the postulated link between inadequate selenium supply and overt autoimmune thyroid disease, especially GD." @default.
• W2104548717 created "2016-06-24" @default.
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• W2104548717 date "2013-03-27" @default.
• W2104548717 modified "2023-10-18" @default.
• W2104548717 title "Serum selenium is low in newly diagnosed Graves’ disease: a population-based study" @default.
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• W2104548717 doi "https://doi.org/10.1111/cen.12185" @default.
• W2104548717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23448365" @default.
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