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- W2104564488 abstract "Three-dimensional (3-D) tissue imaging offers substantial benefits to a wide range of biomedical investigations from cardiovascular biology, diabetes, Alzheimer's disease to cancer. Two-photon tissue cytometry is a novel technique based on high-speed multiphoton microscopy coupled with automated histological sectioning, which can quantify tissue morphology and physiology throughout entire organs with subcellular resolution. Furthermore, two-photon tissue cytometry offers all the benefits of fluorescence-based approaches including high specificity and sensitivity and appropriateness for molecular imaging of gene and protein expression. We use two-photon tissue cytometry to image an entire mouse heart at subcellular resolution to quantify the 3-D morphology of cardiac microvasculature and myocyte morphology spanning almost five orders of magnitude in length scales." @default.
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- W2104564488 date "2007-01-01" @default.
- W2104564488 modified "2023-10-11" @default.
- W2104564488 title "High-resolution whole organ imaging using two-photon tissue cytometry" @default.
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- W2104564488 doi "https://doi.org/10.1117/1.2435626" @default.
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