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• W2104570745 abstract "La radiothérapie des tumeurs gliales évolue rapidement avec les progrès diagnostiques et thérapeutiques récemment acquis. Parmi les aspects techniques, les progrès en imagerie aident à une meilleure analyse des volumes-cibles anatomocliniques. L’apport de l’imagerie morphologique et fonctionnelle devrait faciliter le ciblage des zones à risque de poursuite évolutive et de rechute et une meilleure délinéation des organes à risques. Le développement des techniques d’irradiation non coplanaires, des irradiations conformationnelle avec modulation d’intensité, facilite la protection du cerveau sain et des organes à risque intra- et extracrâniens et permet une éventuelle intensification de dose dans les volumes-cibles. Les progrès thérapeutiques, modestes mais indéniables, reposent sur les associations thérapeutiques de la radiothérapie avec la chimiothérapie et la chirurgie. L’évaluation du terrain, en particulier chez le sujet âgé, l’apport de critères biologiques (déletion 1p, 19 q et méthylation de la MGMT) et l’utilisation de nouveaux traitements justifient une prise en charge multidisciplinaire et une forte implication en recherche clinique. Radiotherapy of glial tumors is rapidly evolving with the recent technical and therapeutic progress. About technical aspects, progress in technical imaging and development of non-coplanar conformal and IMRT techniques provide new possibilities for sparing healthy tissue while increasing dose in tumoral volume. Furthermore, functional and molecular imaging are helpful for delineation and for prediction of relapse. Even modest, the actual improvement of survival with radiochemotherapy leads now to new and important developments for clinical research according to clincal data (age, general status), biological data (MGMT promotor methylation and cytogenetic modifications) and technical data (quality of surgery and radiotherapy). Understanding of molecular mechanisms allows for rational targeting or specific pathways of repair, signaling angiogenesis associated with surgery and radiotherapy in a multidisciplinary approach." @default.
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• W2104570745 date "2008-11-01" @default.
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• W2104570745 title "Radiothérapie des tumeurs gliales : techniques et indications" @default.
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• W2104570745 doi "https://doi.org/10.1016/j.canrad.2008.09.004" @default.
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