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- W2104583132 abstract "Intervertebral disc degeneration (IDD) is a common orthopedic disease associated with mechanical changes that may result in significant pain. Current treatments for IDD mainly depend on conservative therapies and spinal surgeries that are only able to relieve the symptoms but do not address the cause of the degeneration and even accelerate the degeneration of adjacent segments. This has prompted research to improve our understanding of the biology of intervertebral disc healing and into methods to enhance the regenerative process. Recently, biological therapies, including active substances, gene therapy and tissue engineering based on certain cells, have been attracting more attention in the field of intervertebral disc repair and regeneration. Early selection of suitable biological treatment is an ideal way to prevent or even reverse the progressive trend of IDD. Growth factors have been enjoying more popularity in the field of regeneration of IDD and many have been proved to be effective in reversing the degenerative trend of the intervertebral disc. Identification of these growth factors has led to strategies to deliver platelet-derived factors to the intervertebral disc for regeneration. Platelet-rich plasma (PRP) is the latest technique to be evaluated for promoting intervertebral disc healing. Activation of the PRP leads to the release of growth factors from the α-granules in the platelet cytoplasm. These growth factors have been associated with the initiation of a healing cascade that leads to cellular chemotaxis, angiogenesis, synthesis of collagen matrix, and cell proliferation. This review describes the current understanding of IDD and related biological therapeutic strategies, especially the promising prospects of PRP treatment. Future limitations and perspectives of PRP therapy for IDD are also discussed." @default.
- W2104583132 created "2016-06-24" @default.
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- W2104583132 date "2013-01-01" @default.
- W2104583132 modified "2023-10-16" @default.
- W2104583132 title "Enhancing intervertebral disc repair and regeneration through biology: platelet-rich plasma as an alternative strategy" @default.
- W2104583132 cites W1007959536 @default.
- W2104583132 cites W127220886 @default.
- W2104583132 cites W1482343191 @default.
- W2104583132 cites W1545104914 @default.
- W2104583132 cites W1965282660 @default.
- W2104583132 cites W1972802528 @default.
- W2104583132 cites W1973847681 @default.
- W2104583132 cites W1974410142 @default.
- W2104583132 cites W1975225259 @default.
- W2104583132 cites W1991606527 @default.
- W2104583132 cites W1995306753 @default.
- W2104583132 cites W1995650257 @default.
- W2104583132 cites W1995869085 @default.
- W2104583132 cites W1997420170 @default.
- W2104583132 cites W2000165235 @default.
- W2104583132 cites W2000307014 @default.
- W2104583132 cites W2002078337 @default.
- W2104583132 cites W2003431399 @default.
- W2104583132 cites W2006461303 @default.
- W2104583132 cites W2006803278 @default.
- W2104583132 cites W2011570852 @default.
- W2104583132 cites W2016794937 @default.
- W2104583132 cites W2017461581 @default.
- W2104583132 cites W2019977717 @default.
- W2104583132 cites W2021412978 @default.
- W2104583132 cites W2026033806 @default.
- W2104583132 cites W2029307705 @default.
- W2104583132 cites W2036586548 @default.
- W2104583132 cites W2037328562 @default.
- W2104583132 cites W2037790690 @default.
- W2104583132 cites W2037863210 @default.
- W2104583132 cites W2040962303 @default.
- W2104583132 cites W2041089451 @default.
- W2104583132 cites W2049539822 @default.
- W2104583132 cites W2050891920 @default.
- W2104583132 cites W2051052857 @default.
- W2104583132 cites W2052511585 @default.
- W2104583132 cites W2055966310 @default.
- W2104583132 cites W2056732606 @default.
- W2104583132 cites W2064413596 @default.
- W2104583132 cites W2066496557 @default.
- W2104583132 cites W2067364761 @default.
- W2104583132 cites W2068030474 @default.
- W2104583132 cites W2070974884 @default.
- W2104583132 cites W2071237033 @default.
- W2104583132 cites W2071983551 @default.
- W2104583132 cites W2076098443 @default.
- W2104583132 cites W2078850755 @default.
- W2104583132 cites W2081893439 @default.
- W2104583132 cites W2094614331 @default.
- W2104583132 cites W2106031716 @default.
- W2104583132 cites W2110284689 @default.
- W2104583132 cites W2120769001 @default.
- W2104583132 cites W2128431867 @default.
- W2104583132 cites W2130733926 @default.
- W2104583132 cites W2139693718 @default.
- W2104583132 cites W2143018793 @default.
- W2104583132 cites W2146837307 @default.
- W2104583132 cites W2148993566 @default.
- W2104583132 cites W2152983876 @default.
- W2104583132 cites W2153874248 @default.
- W2104583132 cites W2155707831 @default.
- W2104583132 cites W2168952242 @default.
- W2104583132 cites W2317718261 @default.
- W2104583132 cites W2337254306 @default.
- W2104583132 cites W2376667391 @default.
- W2104583132 cites W2406721410 @default.
- W2104583132 cites W32807566 @default.
- W2104583132 cites W66791866 @default.
- W2104583132 cites W2017384250 @default.
- W2104583132 doi "https://doi.org/10.1186/ar4353" @default.
- W2104583132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3978730" @default.
- W2104583132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24165687" @default.
- W2104583132 hasPublicationYear "2013" @default.
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