FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104610389> ?p ?o ?g. }

• W2104610389 endingPage "2202" @default.
• W2104610389 startingPage "2194" @default.
• W2104610389 abstract "ABSTRACT Fur is an iron-binding transcriptional repressor that recognizes a 19-bp consensus site of the sequence 5′-GATAATGATAATCATTATC-3′. This site can be defined as three adjacent hexamers of the sequence 5′-GATAAT-3′, with the third being slightly imperfect (an F-F-F configuration), or as two hexamers in the forward orientation separated by one base pair from a third hexamer in the reverse orientation (an F-F-x-R configuration). Although Fur can bind synthetic DNA sequences containing the F-F-F arrangement, most natural binding sites are variations of the F-F-x-R arrangement. The studies presented here compared the ability of Fur to recognize synthetic DNA sequences containing two to four adjacent hexamers with binding to sequences containing variations of the F-F-x-R arrangement (including natural operator sequences from the entS and fepB promoter regions of Escherichia coli ). Gel retardation assays showed that the F-F-x-R architecture was necessary for high-affinity Fur-DNA interactions and that contiguous hexamers were not recognized as effectively. In addition, the stoichiometry of Fur at each binding site was determined, showing that Fur interacted with its minimal 19-bp binding site as two overlapping dimers. These data confirm the proposed overlapping-dimer binding model, where the unit of interaction with a single Fur dimer is two inverted hexamers separated by a C:G base pair, with two overlapping units comprising the 19-bp consensus binding site required for the high-affinity interaction with two Fur dimers." @default.
• W2104610389 created "2016-06-24" @default.
• W2104610389 creator A5021811882 @default.
• W2104610389 creator A5061744168 @default.
• W2104610389 date "2003-04-01" @default.
• W2104610389 modified "2023-10-03" @default.
• W2104610389 title "Architecture of a Fur Binding Site: a Comparative Analysis" @default.
• W2104610389 cites W1501828742 @default.
• W2104610389 cites W1515226138 @default.
• W2104610389 cites W1525270206 @default.
• W2104610389 cites W1572779399 @default.
• W2104610389 cites W1615863739 @default.
• W2104610389 cites W1627110571 @default.
• W2104610389 cites W1837752675 @default.
• W2104610389 cites W1962539160 @default.
• W2104610389 cites W1969435183 @default.
• W2104610389 cites W1978370818 @default.
• W2104610389 cites W1978836455 @default.
• W2104610389 cites W1986738890 @default.
• W2104610389 cites W1990570667 @default.
• W2104610389 cites W1992580173 @default.
• W2104610389 cites W2001779755 @default.
• W2104610389 cites W2007339103 @default.
• W2104610389 cites W2019861012 @default.
• W2104610389 cites W2023983573 @default.
• W2104610389 cites W2029745103 @default.
• W2104610389 cites W2038545761 @default.
• W2104610389 cites W2054631692 @default.
• W2104610389 cites W2057612625 @default.
• W2104610389 cites W2060703599 @default.
• W2104610389 cites W2070643079 @default.
• W2104610389 cites W2072148144 @default.
• W2104610389 cites W2072333420 @default.
• W2104610389 cites W2073169023 @default.
• W2104610389 cites W2074744472 @default.
• W2104610389 cites W2077583943 @default.
• W2104610389 cites W2104315311 @default.
• W2104610389 cites W2110830984 @default.
• W2104610389 cites W2114187319 @default.
• W2104610389 cites W2123644073 @default.
• W2104610389 cites W2124372396 @default.
• W2104610389 cites W2126840804 @default.
• W2104610389 cites W2130043185 @default.
• W2104610389 cites W2140702033 @default.
• W2104610389 cites W2142120140 @default.
• W2104610389 cites W2163977322 @default.
• W2104610389 cites W2765289022 @default.
• W2104610389 doi "https://doi.org/10.1128/jb.185.7.2194-2202.2003" @default.
• W2104610389 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/151488" @default.
• W2104610389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12644489" @default.
• W2104610389 hasPublicationYear "2003" @default.
• W2104610389 type Work @default.
• W2104610389 sameAs 2104610389 @default.
• W2104610389 citedByCount "90" @default.
• W2104610389 countsByYear W21046103892012 @default.
• W2104610389 countsByYear W21046103892013 @default.
• W2104610389 countsByYear W21046103892014 @default.
• W2104610389 countsByYear W21046103892015 @default.
• W2104610389 countsByYear W21046103892016 @default.
• W2104610389 countsByYear W21046103892017 @default.
• W2104610389 countsByYear W21046103892018 @default.
• W2104610389 countsByYear W21046103892019 @default.
• W2104610389 countsByYear W21046103892020 @default.
• W2104610389 countsByYear W21046103892021 @default.
• W2104610389 countsByYear W21046103892022 @default.
• W2104610389 countsByYear W21046103892023 @default.
• W2104610389 crossrefType "journal-article" @default.
• W2104610389 hasAuthorship W2104610389A5021811882 @default.
• W2104610389 hasAuthorship W2104610389A5061744168 @default.
• W2104610389 hasBestOaLocation W21046103891 @default.
• W2104610389 hasConcept C101762097 @default.
• W2104610389 hasConcept C104317684 @default.
• W2104610389 hasConcept C107824862 @default.
• W2104610389 hasConcept C150194340 @default.
• W2104610389 hasConcept C153911025 @default.
• W2104610389 hasConcept C158448853 @default.
• W2104610389 hasConcept C178790620 @default.
• W2104610389 hasConcept C185581394 @default.
• W2104610389 hasConcept C185592680 @default.
• W2104610389 hasConcept C189754071 @default.
• W2104610389 hasConcept C2778112365 @default.
• W2104610389 hasConcept C2779546866 @default.
• W2104610389 hasConcept C3017666073 @default.
• W2104610389 hasConcept C3662595 @default.
• W2104610389 hasConcept C54355233 @default.
• W2104610389 hasConcept C54985914 @default.
• W2104610389 hasConcept C552990157 @default.
• W2104610389 hasConcept C71240020 @default.
• W2104610389 hasConcept C8010536 @default.
• W2104610389 hasConcept C86339819 @default.
• W2104610389 hasConcept C86803240 @default.
• W2104610389 hasConceptScore W2104610389C101762097 @default.
• W2104610389 hasConceptScore W2104610389C104317684 @default.
• W2104610389 hasConceptScore W2104610389C107824862 @default.
• W2104610389 hasConceptScore W2104610389C150194340 @default.
• W2104610389 hasConceptScore W2104610389C153911025 @default.
• W2104610389 hasConceptScore W2104610389C158448853 @default.
• W2104610389 hasConceptScore W2104610389C178790620 @default.

• next