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• W2104613439 abstract "To evaluate the effects of dexmedetomidine, an alpha-2 agonist, as an intravenous sedative drug and the effects of atipamezole, an alpha-2 antagonist, on recovery.Randomized, double-blind study with three parallel groups. An open dose-finding study preceded it to optimize the atipamezole dose.Outpatient operating room at the gynecologic and obstetric university hospital in Helsinki, Finland.Seventy-two healthy women scheduled for legal termination of pregnancy.Patients were assigned to one of three groups of 24 patients each to receive either dexmedetomidine 2 micrograms/kg and atipamezole 50 micrograms/kg; dexmetomidine 2 micrograms/kg and saline; or midazolam 0.15 mg/kg and saline. In addition to paracervical block, each patient received two different study drugs: study drug 1 was a sedative agent (either dexmedetomidine or midazolam), administered before the procedure. If the sedation was not deep enough and the patient reacted to the procedure, a low dose of propofol was administered. Study drug 2 was a reversing agent or a placebo, administered following the procedure.The mean time to regain consciousness was shorter in the dexmedetomidine-atipamezole and the dexmedetomidine-saline groups compared with the midazolam group. Postoperative sedation, tested both by subjective and objective assessments, decreased more quickly in the dexmedetomidine-atipamezole group compared with the dexmedetomidine-saline and the midazolam groups.Atipamezole is an effective antagonist for reversing psychomotor impairment following dexmedetomidine sedation." @default.
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• W2104613439 date "1993-05-01" @default.
• W2104613439 modified "2023-10-11" @default.
• W2104613439 title "Comparison of dexmedetomidine and midazolam sedation and antagonism of dexmedetomidine with atipamezole" @default.
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• W2104613439 doi "https://doi.org/10.1016/0952-8180(93)90014-6" @default.
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