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• W2104689561 abstract "To determine if diet composition influences responses to GH, we fed 11 obese women diets containing 12 Cal/kg ideal BW (IBW) for 2 5-week study intervals. Nonprotein calories were supplied to 6 subjects as 72% carbohydrate (high carbohydrate diet), and 5 subjects received 80% of their nonprotein calories as lip id (high lipid diet). Protein intake was constant (1.0 g/kg IBW) in both groups. During 1 study interval we gave injections of GH (0.1 mg/kg IBW) every other day for 3 weeks (weeks 2–4), and in the other interval injections of vehicle were given. Subjects ingesting the high carbohydrate diet excreted significantly less urinary nitrogen [660.2 ± 124.1 mmol/day (mean ± sd)] than those who received high lipid (794.2 ± 198.5 mmol/day; P < 0.001), and GH injections reduced nitrogen excretion in the high carbohydrate subjects (532.8 ± 123.8 mmol/day), but not in the high lipid subjects (743.7 ± 126.6 mmol/day). The subjects receiving the high carbohydrate diet had a significant increase in serum insulin-like growth factor-I (IGFI; from 36.2 ± 9.7 to 55.9 ± 6.6 nmol/L) and urinary C-peptide excretion (from 43.9 ± 25.6 to 60.8 ± 29.4 nmol/day) in response to GH. The IGF-I response attenuated slowly over the 3-week treatment interval. On the other hand, the high lipid group had lesser increases in IGF-I (from 31.0 ± 6.5 to 41.7 ± 8.8 nmol/L) and C-peptide excretion (from 24.3 ± 28.9 to 29.8 ± 32.8 nmol/day), and IGF-I concentrations declined to control values after only 5 days of GH injection. We believe that this initial IGF-I response was due to an antecedent 35-Cal balanced diet. The mean increment in serum FFA 4 h after GH injection was significantly less in subjects fed the high lipid diet (0.53 ± 0.40 meq/L) than in those fed the high carbohydrate diet (0.83 ± 0.43 meq/L). GH injections produced more body fat loss than injections of vehicle whether expressed as percent body fat lost (GH, 3.7 ± 1.0%; vehicle, 2.8 ± 0.7%, P < 0.05) or as the fraction of weight lost as fat (fat loss/weight loss; GH, 0.81 ± 0.13; vehicle, 0.64 ± 0.08; P < 0.005). There was an inverse correlation between the percentage of body fat lost and mean urinary Cpeptide excretion during GH injections (r = −0.70; P < 0.05), suggesting that stimulation of insulin secretion by GH might antagonize the tendency of GH to promote fat loss. These results suggest that when caloric restriction is severe, carbohydrate intake becomes a major determinant of GH responsiveness. Because the IGF-I and other metabolic responses to exogenous GH are dependent on adequate dietary carbohydrate, we speculate that at least some of the nitrogen-sparing effects observed when high carbohydrate diets are ingested may be mediated by endogenous GH and IGF-I. (J Clin Endocrinol Metab69: 745, 1989)" @default.
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• W2104689561 date "1989-10-01" @default.
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• W2104689561 title "Dietary Carbohydrate Content Determines Responsiveness to Growth Hormone in Energy-Restricted Humans*" @default.
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• W2104689561 doi "https://doi.org/10.1210/jcem-69-4-745" @default.
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