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• W2104702563 abstract "Parkinson's disease (PD) is a neurodegenerative disease, which is characterized by progressive death of dopaminergic neurons in the substantia nigra pars compacta. Although mitochondrial dysfunction and oxidative stress are linked to PD pathogenesis, its etiology and pathology remain to be elucidated. Metabolomics investigates metabolite changes in biofluids, cell lysates, tissues and tumors in order to correlate these metabolomic changes to a disease state. Thus, the application of metabolomics to investigate PD provides a systematic approach to understand the pathology of PD, to identify disease biomarkers, and to complement genomics, transcriptomics and proteomics studies. This review will examine current research into PD mechanisms with a focus on mitochondrial dysfunction and oxidative stress. Neurotoxin- based PD animal models and the rationale for metabolomics studies in PD will also be discussed. The review will also explore the potential of NMR metabolomics to address important issues related to PD treatment and diagnosis." @default.
• W2104702563 created "2016-06-24" @default.
• W2104702563 creator A5005993648 @default.
• W2104702563 creator A5016524389 @default.
• W2104702563 date "2013-09-01" @default.
• W2104702563 modified "2023-10-16" @default.
• W2104702563 title "NMR Metabolomics Analysis of Parkinson&#39;s Disease" @default.
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