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- W2104717580 endingPage "735" @default.
- W2104717580 startingPage "719" @default.
- W2104717580 abstract "Aging is a major risk factor for neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). An unbalanced overproduction of reactive oxygen species (ROS) may give rise to oxidative stress which can induce neuronal damage, ultimately leading to neuronal death by apoptosis or necrosis. A large body of evidence indicates that oxidative stress is involved in the pathogenesis of AD, PD, and ALS. An increasing number of studies show that nutritional antioxidants (especially Vitamin E and polyphenols) can block neuronal death in vitro, and may have therapeutic properties in animal models of neurodegenerative diseases including AD, PD, and ALS. Moreover, clinical data suggest that nutritional antioxidants might exert some protective effect against AD, PD, and ALS. In this paper, the biochemical mechanisms by which nutritional antioxidants can reduce or block neuronal death occurring in neurodegenerative disorders are reviewed. Particular emphasis will be given to the role played by the nuclear transcription factor-kappaB (NF-kappaB) in apoptosis, and in the pathogenesis of neurodegenerative disorders, such as AD, PD, and ALS. The effects of ROS and antioxidants on NF-kappaB function and their relevance in the pathophysiology of neurodegenerative diseases will also be examined." @default.
- W2104717580 created "2016-06-24" @default.
- W2104717580 creator A5046342727 @default.
- W2104717580 creator A5053248832 @default.
- W2104717580 creator A5060441165 @default.
- W2104717580 creator A5070275576 @default.
- W2104717580 creator A5075322474 @default.
- W2104717580 creator A5089668241 @default.
- W2104717580 date "2002-09-01" @default.
- W2104717580 modified "2023-10-16" @default.
- W2104717580 title "A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes" @default.
- W2104717580 cites W1023155169 @default.
- W2104717580 cites W111387551 @default.
- W2104717580 cites W1238680464 @default.
- W2104717580 cites W1261198562 @default.
- W2104717580 cites W143301983 @default.
- W2104717580 cites W1481697456 @default.
- W2104717580 cites W1483563853 @default.
- W2104717580 cites W1490128449 @default.
- W2104717580 cites W1504584187 @default.
- W2104717580 cites W1507112934 @default.
- W2104717580 cites W1515578871 @default.
- W2104717580 cites W1519463750 @default.
- W2104717580 cites W1530276807 @default.
- W2104717580 cites W1537390295 @default.
- W2104717580 cites W1540436551 @default.
- W2104717580 cites W1542061701 @default.
- W2104717580 cites W1542152284 @default.
- W2104717580 cites W1549857563 @default.
- W2104717580 cites W1560505179 @default.
- W2104717580 cites W1564588342 @default.
- W2104717580 cites W1568529372 @default.
- W2104717580 cites W1571764227 @default.
- W2104717580 cites W1574464726 @default.
- W2104717580 cites W1574544450 @default.
- W2104717580 cites W1575495254 @default.
- W2104717580 cites W1577403013 @default.
- W2104717580 cites W1590514634 @default.
- W2104717580 cites W1621509181 @default.
- W2104717580 cites W166102277 @default.
- W2104717580 cites W1662308449 @default.
- W2104717580 cites W1718709781 @default.
- W2104717580 cites W177797889 @default.
- W2104717580 cites W1796430339 @default.
- W2104717580 cites W1807257653 @default.
- W2104717580 cites W1820596764 @default.
- W2104717580 cites W1872376120 @default.
- W2104717580 cites W1888783223 @default.
- W2104717580 cites W1929245453 @default.
- W2104717580 cites W1934800228 @default.
- W2104717580 cites W1940344336 @default.
- W2104717580 cites W1952402412 @default.
- W2104717580 cites W1956108500 @default.
- W2104717580 cites W1957382934 @default.
- W2104717580 cites W1960735897 @default.
- W2104717580 cites W1963917943 @default.
- W2104717580 cites W1964747384 @default.
- W2104717580 cites W1964780858 @default.
- W2104717580 cites W1968537977 @default.
- W2104717580 cites W1968786165 @default.
- W2104717580 cites W1969257616 @default.
- W2104717580 cites W1969280474 @default.
- W2104717580 cites W1969800514 @default.
- W2104717580 cites W1970603050 @default.
- W2104717580 cites W1970921883 @default.
- W2104717580 cites W1971032331 @default.
- W2104717580 cites W1975481676 @default.
- W2104717580 cites W1977069725 @default.
- W2104717580 cites W1977406521 @default.
- W2104717580 cites W1977817124 @default.
- W2104717580 cites W1978688182 @default.
- W2104717580 cites W1978701238 @default.
- W2104717580 cites W1978874104 @default.
- W2104717580 cites W1979496463 @default.
- W2104717580 cites W1980160486 @default.
- W2104717580 cites W1980825813 @default.
- W2104717580 cites W1980855715 @default.
- W2104717580 cites W1981166064 @default.
- W2104717580 cites W1981354055 @default.
- W2104717580 cites W1981513372 @default.
- W2104717580 cites W1982070131 @default.
- W2104717580 cites W1983493663 @default.
- W2104717580 cites W1983668432 @default.
- W2104717580 cites W1984940419 @default.
- W2104717580 cites W1985613988 @default.
- W2104717580 cites W1985904485 @default.
- W2104717580 cites W1987510933 @default.
- W2104717580 cites W1989530212 @default.
- W2104717580 cites W1991511436 @default.
- W2104717580 cites W1991743392 @default.
- W2104717580 cites W1992813727 @default.
- W2104717580 cites W1993266132 @default.
- W2104717580 cites W1993336124 @default.
- W2104717580 cites W1995379683 @default.
- W2104717580 cites W1995505431 @default.
- W2104717580 cites W1996175319 @default.
- W2104717580 cites W1996311437 @default.
- W2104717580 cites W1996766499 @default.