Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104757650> ?p ?o ?g. }
- W2104757650 endingPage "230" @default.
- W2104757650 startingPage "218" @default.
- W2104757650 abstract "The biological interface between an orthopedic implant and the surrounding host tissue may have a dramatic effect upon clinical outcome. Desired effects include bony ingrowth (osseointegration), stimulation of osteogenesis (osteoinduction), increased vascularization, and improved mechanical stability. Implant loosening, fibrous encapsulation, corrosion, infection, and inflammation, as well as physical mismatch may have deleterious clinical effects. This is particularly true of implants used in the reconstruction of load-bearing synovial joints such as the knee, hip, and the shoulder. The surfaces of orthopedic implants have evolved from solid-smooth to roughened-coarse and most recently, to porous in an effort to create a three-dimensional architecture for bone apposition and osseointegration. Total joint surgeries are increasingly performed in younger individuals with a longer life expectancy, and therefore, the postimplantation lifespan of devices must increase commensurately. This review discusses advancements in biomaterials science and cell-based therapies that may further improve orthopedic success rates. We focus on material and biological properties of orthopedic implants fabricated from porous metal and highlight some relevant developments in stem-cell research. We posit that the ideal primary and revision orthopedic load-bearing metal implants are highly porous and may be chemically modified to induce stem cell growth and osteogenic differentiation, while minimizing inflammation and infection. We conclude that integration of new biological, chemical, and mechanical methods is likely to yield more effective strategies to control and modify the implant-bone interface and thereby improve long-term clinical outcomes." @default.
- W2104757650 created "2016-06-24" @default.
- W2104757650 creator A5002285513 @default.
- W2104757650 creator A5002325521 @default.
- W2104757650 creator A5008755139 @default.
- W2104757650 creator A5029187007 @default.
- W2104757650 creator A5035972380 @default.
- W2104757650 creator A5039689056 @default.
- W2104757650 creator A5066191548 @default.
- W2104757650 creator A5072285339 @default.
- W2104757650 creator A5082473575 @default.
- W2104757650 creator A5083397889 @default.
- W2104757650 date "2015-04-01" @default.
- W2104757650 modified "2023-09-30" @default.
- W2104757650 title "Biological Strategies for Improved Osseointegration and Osteoinduction of Porous Metal Orthopedic Implants" @default.
- W2104757650 cites W125852739 @default.
- W2104757650 cites W1507716108 @default.
- W2104757650 cites W1533068651 @default.
- W2104757650 cites W1547994764 @default.
- W2104757650 cites W1765554953 @default.
- W2104757650 cites W1896480138 @default.
- W2104757650 cites W1953530396 @default.
- W2104757650 cites W1959688202 @default.
- W2104757650 cites W1965925756 @default.
- W2104757650 cites W1968479596 @default.
- W2104757650 cites W1970144926 @default.
- W2104757650 cites W1975603068 @default.
- W2104757650 cites W1976865990 @default.
- W2104757650 cites W1977280332 @default.
- W2104757650 cites W1978778471 @default.
- W2104757650 cites W1979323707 @default.
- W2104757650 cites W1980181526 @default.
- W2104757650 cites W1980547794 @default.
- W2104757650 cites W1980959628 @default.
- W2104757650 cites W1981889116 @default.
- W2104757650 cites W1983047103 @default.
- W2104757650 cites W1984721835 @default.
- W2104757650 cites W1985147143 @default.
- W2104757650 cites W1985990366 @default.
- W2104757650 cites W1986228673 @default.
- W2104757650 cites W1986677098 @default.
- W2104757650 cites W1988441621 @default.
- W2104757650 cites W1988881359 @default.
- W2104757650 cites W1990611513 @default.
- W2104757650 cites W1994995145 @default.
- W2104757650 cites W1996328356 @default.
- W2104757650 cites W1997274786 @default.
- W2104757650 cites W1997336072 @default.
- W2104757650 cites W1997763705 @default.
- W2104757650 cites W1998725904 @default.
- W2104757650 cites W1999242671 @default.
- W2104757650 cites W1999725217 @default.
- W2104757650 cites W2000123764 @default.
- W2104757650 cites W2000363357 @default.
- W2104757650 cites W2006096131 @default.
- W2104757650 cites W2006563583 @default.
- W2104757650 cites W2007541978 @default.
- W2104757650 cites W2007965943 @default.
- W2104757650 cites W2007996527 @default.
- W2104757650 cites W2008158617 @default.
- W2104757650 cites W2008503883 @default.
- W2104757650 cites W2009239849 @default.
- W2104757650 cites W2010473896 @default.
- W2104757650 cites W2013066063 @default.
- W2104757650 cites W2013976086 @default.
- W2104757650 cites W2015516254 @default.
- W2104757650 cites W2017426973 @default.
- W2104757650 cites W2017769559 @default.
- W2104757650 cites W2018145050 @default.
- W2104757650 cites W2018459010 @default.
- W2104757650 cites W2020840867 @default.
- W2104757650 cites W2021420116 @default.
- W2104757650 cites W2022898572 @default.
- W2104757650 cites W2023977237 @default.
- W2104757650 cites W2027403719 @default.
- W2104757650 cites W2028011772 @default.
- W2104757650 cites W2033323849 @default.
- W2104757650 cites W2036423089 @default.
- W2104757650 cites W2037075839 @default.
- W2104757650 cites W2038806616 @default.
- W2104757650 cites W2038844087 @default.
- W2104757650 cites W2040961527 @default.
- W2104757650 cites W2043819675 @default.
- W2104757650 cites W2044011855 @default.
- W2104757650 cites W2045168235 @default.
- W2104757650 cites W2045985308 @default.
- W2104757650 cites W2047087395 @default.
- W2104757650 cites W2048550500 @default.
- W2104757650 cites W2051085059 @default.
- W2104757650 cites W2051392467 @default.
- W2104757650 cites W2052111549 @default.
- W2104757650 cites W2052470498 @default.
- W2104757650 cites W2055248506 @default.
- W2104757650 cites W2056670631 @default.
- W2104757650 cites W2063418008 @default.
- W2104757650 cites W2063736731 @default.
- W2104757650 cites W2065570690 @default.
- W2104757650 cites W2066624578 @default.