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• W2104760708 abstract "Autophagy, the process for recycling cytoplasm in the lysosome, depends on membrane trafficking. We previously identified Drosophila Sbf as a Rab21 guanine nucleotide exchange factor (GEF) that acts with Rab21 in endosomal trafficking. Here, we show that Sbf/MTMR13 and Rab21 have conserved functions required for starvation-induced autophagy. Depletion of Sbf/MTMR13 or Rab21 blocked endolysosomal trafficking of VAMP8, a SNARE required for autophagosome-lysosome fusion. We show that starvation induces Sbf/MTMR13 GEF and RAB21 activity, as well as their induced binding to VAMP8 (or closest Drosophila homolog, Vamp7). MTMR13 is required for RAB21 activation, VAMP8 interaction and VAMP8 endolysosomal trafficking, defining a novel GEF-Rab-effector pathway. These results identify starvation-responsive endosomal regulators and trafficking that tunes membrane demands with changing autophagy status." @default.
• W2104760708 created "2016-06-24" @default.
• W2104760708 creator A5015799919 @default.
• W2104760708 creator A5019231504 @default.
• W2104760708 creator A5020140046 @default.
• W2104760708 creator A5026249209 @default.
• W2104760708 date "2015-02-03" @default.
• W2104760708 modified "2023-10-17" @default.
• W2104760708 title "Starvation‐induced <scp>MTMR</scp> 13 and <scp>RAB</scp> 21 activity regulates <scp>VAMP</scp> 8 to promote autophagosome–lysosome fusion" @default.
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• W2104760708 doi "https://doi.org/10.15252/embr.201439464" @default.
• W2104760708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4364869" @default.
• W2104760708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25648148" @default.
• W2104760708 hasPublicationYear "2015" @default.
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