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• W2104780147 abstract "In the pediatric population, altered busulfan pharmacokinetics have been described in patients less than 4 years of age. Higher doses of busulfan have been utilized to ensure therapeutic drug levels are achieved. Patients less than 1 year of age are included in this higher dosing strategy although the data in this population is minimal. The purpose of this study was to characterize the dosing of patients less than 1 year of age and compare the cumulative busulfan dose received to that of patients between 1 and 4 years of age. A retrospective review was performed and included sixteen patients less than 4 years of age who received intravenous busulfan as part of a conditioning regimen prior to transplant. The cumulative busulfan dose was calculated to assess the primary endpoint. Secondary endpoints included evaluation of toxicities and engraftment. Of the sixteen patients, ten patients were between 1 and 4 years of age and six patients were less than 1 year of age. The initial busulfan dose was similar between groups with children less than 1 year of age receiving a mean of 0.93 mg/kg/dose (range 0.8-1 mg/kg/dose) compared to 0.99 mg/kg/dose (range 0.8-1.28 mg/kg/dose) in the 1-4 year group (p = 0.4). Pharmacokinetic analysis was performed in 15 patients (94%). Eight patients (80%) in the 1-4 year group required an increased dose, while two patients (33%) required a decrease in the less than 1 year group. The mean cumulative busulfan dose was significantly higher in the 1-4 year group, 1.15 mg/kg/dose (range 1-1.4 mg/kg/dose) compared to 0.92 mg/kg/dose (range 0.69-1.3 mg/kg/dose) in the less than 1 year group (p = 0.01). Engraftment and toxicities were also evaluated in this patient population. Veno-occlusive disease was diagnosed in two patients (33.3%) in the less than 1 year group and no cases were reported in the 1-4 year group. Engraftment was delayed in the 1-4 year group at 25 days compared to 16 days in the less than 1 year group (p = 0.01). Graft failure occurred in one patient (10%) in the 1-4 year group. Patients less than 1 year of age required significantly lower cumulative busulfan doses to maintain therapeutic levels compared to patients in the 1-4 year age group. Strategies to optimize the dosing of busulfan in patients less than 1 year of age warrant further investigation." @default.
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• W2104780147 date "2011-02-01" @default.
• W2104780147 modified "2023-09-27" @default.
• W2104780147 title "Characterization of Busulfan Dose in Hematopoietic Stem Cell Transplant Patients Less Than 12 Months of Age" @default.
• W2104780147 doi "https://doi.org/10.1016/j.bbmt.2010.12.118" @default.
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