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- W2104785672 abstract "An in vitro perifusion system was used to investigate the effect of progesterone (P4) and 20 alpha-hydroxyprogesterone (20 alpha-OHP) on the release of GnRH from isolated hypothalamic tissue of the adult ovariectomized estradiol-17 beta primed rat. Pulse delivery of P4 stimulated GnRH release not only from the isolated mediobasal hypothalamus-anterior hypothalamus-preoptic area (MBH-AHPOA) complex but also from the MBH alone. Release of GnRH from the MBH was also increased by 20 alpha-OHP. These results suggest that the in vivo increase of circulating P4 or 20 alpha-OHP associated with the initiation of the preovulatory LH surge may play a role in regulating the timing or amplitude of this surge by directly stimulating the release of GnRH from the MBH." @default.
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- W2104785672 date "1983-03-01" @default.
- W2104785672 modified "2023-09-28" @default.
- W2104785672 title "Progesterone and 20α-hydroxyprogesterone stimulate the in vitro release of GnRH by the isolated mediobasal hypothalamus" @default.
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- W2104785672 doi "https://doi.org/10.1016/0024-3205(83)90919-0" @default.
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