Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104788261> ?p ?o ?g. }
- W2104788261 endingPage "187" @default.
- W2104788261 startingPage "178" @default.
- W2104788261 abstract "Descrever as principais caracteristicas em mulheres com cancer de mama, de acordo com o perfil imuno-histoquimico. A populacao foi composta a partir de coorte hospitalar formada por mulheres com diagnostico de cancer de mama efetuado entre 2003 e 2005 (n = 601) e atendidas em centro de referencia em assistencia oncologica de Juiz de Fora-MG. Foram selecionadas apenas 397 mulheres que possuiam imunohistoquimica completa. Para definicao dos grupos segundo perfil imuno-histoquimico, optou-se por classificacao baseada na avaliacao dos receptores de estrogeno e de progesterona, indice de proliferacao celular Ki67 e superexpressao de HER2. De acordo com os diferentes fenotipos, foram definidos cinco subtipos: luminal A, luminal B-HER2 negativo, luminal B-HER2 positivo, triplo negativo e HER2 superexpresso. A maioria dos pacientes tinha pele branca (80,7%) e era pos-menopausada (64,9%), com idade media de 57,4 anos (±13,5). Ao diagnostico, 57,5% delas tinha tumor de tamanho ≥ 2,0 cm, e 41,7% exibiam comprometimento linfonodal. Os subtipos mais frequentes foram luminal B-HER2 negativo (41,8%) e triplo negativo (24,2%). No subtipo luminal A, 72,1% das pacientes eram pos-menopausadas, enquanto que os maiores percentuais na pre-menopausa foram observados nos subtipos luminal B-HER2 positivo e triplo negativo (45,2% e 44,2%, respectivamente). Verificou-se maior frequencia de tumores > 2,0 cm e com linfonodos comprometidos nos subtipos triplo negativo e HER2 positivo. Esta pesquisa possibilitou avaliar a distribuicao das principais caracteristicas clinicopatologicas e relacionadas aos servicos de saude em coorte de mulheres brasileiras com cancer de mama, segundo os subtipos tumorais imuno-histoquimicos. To describe the main characteristics of women with breast cancer, according to the immunohistochemical profile. The population comprised a hospital cohort, consisting of women diagnosed with breast cancer between 2003 and 2005 (n = 601) and treated at a referral center for cancer care in Juiz de Fora, MG, Brazil. Only 397 women who had complete immunohistochemistry analysis were selected. To define the groups according to the immunohistochemical profile, the assessment of estrogen and progesterone receptors, Ki-67 cell proliferation index, and overexpression of human epidermal growth factor receptor 2 (HER2) was chosen. According to the different phenotypes, five subtypes were defined: luminal A, luminal B HER2 negative, luminal B HER2 positive, triple negative, and HER2 overexpression. Most patients were white (80.7%) and post-menopausal (64.9%), with a mean age of 57.4 years (± 13.5). At diagnosis, 57.5% had tumor size ≥ 2.0 cm, and 41.7% had lymph node involvement. The most common subtypes were luminal B - HER2 negative (41.8%) and triple negative (24.2%). In the luminal A subtype, 72.1% of patients were post-menopausal, while the highest percentage of premenopausal women were observed in the luminal B - HER2 positive and triple negative subtypes (45.2% and 44.2%, respectively). A higher frequency of tumors > 2.0 cm and lymph node involvement was observed in triple negative and HER2 positive subtypes. This study allowed the distribution assessment of the main clinical and pathological characteristics and those related to health services in a cohort of Brazilian women with breast cancer, according to the immunohistochemical tumor subtypes." @default.
- W2104788261 created "2016-06-24" @default.
- W2104788261 creator A5005447472 @default.
- W2104788261 creator A5006830188 @default.
- W2104788261 creator A5007685340 @default.
- W2104788261 creator A5008497580 @default.
- W2104788261 creator A5009718164 @default.
- W2104788261 creator A5015898679 @default.
- W2104788261 creator A5034400029 @default.
- W2104788261 creator A5039723025 @default.
- W2104788261 creator A5065865746 @default.
- W2104788261 creator A5077293962 @default.
- W2104788261 date "2012-03-01" @default.
- W2104788261 modified "2023-10-11" @default.
- W2104788261 title "Perfil imuno-histoquímico e variáveis clinicopatológicas no câncer de mama" @default.
- W2104788261 cites W1577377935 @default.
- W2104788261 cites W1964347343 @default.
- W2104788261 cites W1970935124 @default.
- W2104788261 cites W1981989535 @default.
- W2104788261 cites W1988026472 @default.
- W2104788261 cites W1994361306 @default.
- W2104788261 cites W1995224853 @default.
- W2104788261 cites W2001600877 @default.
- W2104788261 cites W2002587995 @default.
- W2104788261 cites W2017047594 @default.
- W2104788261 cites W2025284198 @default.
- W2104788261 cites W2032894034 @default.
- W2104788261 cites W2034269086 @default.
- W2104788261 cites W2036936708 @default.
- W2104788261 cites W2052856885 @default.
- W2104788261 cites W2070267202 @default.
- W2104788261 cites W2072514758 @default.
- W2104788261 cites W2082326948 @default.
- W2104788261 cites W2087170069 @default.
- W2104788261 cites W2096884232 @default.
- W2104788261 cites W2106787323 @default.
- W2104788261 cites W2113633750 @default.
- W2104788261 cites W2132893003 @default.
- W2104788261 cites W2135736714 @default.
- W2104788261 cites W2149908785 @default.
- W2104788261 cites W2155698800 @default.
- W2104788261 cites W2155834058 @default.
- W2104788261 cites W2157285286 @default.
- W2104788261 cites W2158734599 @default.
- W2104788261 cites W2161426850 @default.
- W2104788261 cites W2161770015 @default.
- W2104788261 cites W2165432902 @default.
- W2104788261 cites W2169078686 @default.
- W2104788261 cites W2170602872 @default.
- W2104788261 cites W2171015116 @default.
- W2104788261 cites W2946779459 @default.
- W2104788261 cites W3172027829 @default.
- W2104788261 cites W4231018668 @default.
- W2104788261 doi "https://doi.org/10.1590/s0104-42302012000200013" @default.
- W2104788261 hasPublicationYear "2012" @default.
- W2104788261 type Work @default.
- W2104788261 sameAs 2104788261 @default.
- W2104788261 citedByCount "16" @default.
- W2104788261 countsByYear W21047882612012 @default.
- W2104788261 countsByYear W21047882612013 @default.
- W2104788261 countsByYear W21047882612015 @default.
- W2104788261 countsByYear W21047882612016 @default.
- W2104788261 countsByYear W21047882612017 @default.
- W2104788261 countsByYear W21047882612018 @default.
- W2104788261 countsByYear W21047882612019 @default.
- W2104788261 countsByYear W21047882612020 @default.
- W2104788261 countsByYear W21047882612021 @default.
- W2104788261 countsByYear W21047882612022 @default.
- W2104788261 countsByYear W21047882612023 @default.
- W2104788261 crossrefType "journal-article" @default.
- W2104788261 hasAuthorship W2104788261A5005447472 @default.
- W2104788261 hasAuthorship W2104788261A5006830188 @default.
- W2104788261 hasAuthorship W2104788261A5007685340 @default.
- W2104788261 hasAuthorship W2104788261A5008497580 @default.
- W2104788261 hasAuthorship W2104788261A5009718164 @default.
- W2104788261 hasAuthorship W2104788261A5015898679 @default.
- W2104788261 hasAuthorship W2104788261A5034400029 @default.
- W2104788261 hasAuthorship W2104788261A5039723025 @default.
- W2104788261 hasAuthorship W2104788261A5065865746 @default.
- W2104788261 hasAuthorship W2104788261A5077293962 @default.
- W2104788261 hasBestOaLocation W21047882612 @default.
- W2104788261 hasConcept C121608353 @default.
- W2104788261 hasConcept C126322002 @default.
- W2104788261 hasConcept C29456083 @default.
- W2104788261 hasConcept C530470458 @default.
- W2104788261 hasConcept C71924100 @default.
- W2104788261 hasConceptScore W2104788261C121608353 @default.
- W2104788261 hasConceptScore W2104788261C126322002 @default.
- W2104788261 hasConceptScore W2104788261C29456083 @default.
- W2104788261 hasConceptScore W2104788261C530470458 @default.
- W2104788261 hasConceptScore W2104788261C71924100 @default.
- W2104788261 hasIssue "2" @default.
- W2104788261 hasLocation W21047882611 @default.
- W2104788261 hasLocation W21047882612 @default.
- W2104788261 hasLocation W21047882613 @default.
- W2104788261 hasOpenAccess W2104788261 @default.
- W2104788261 hasPrimaryLocation W21047882611 @default.
- W2104788261 hasRelatedWork W1595863544 @default.