FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104790095> ?p ?o ?g. }

• W2104790095 endingPage "128" @default.
• W2104790095 startingPage "122" @default.
• W2104790095 abstract "Alterations in Ca 2+ homeostasis and accumulation of unfolded proteins in the endoplasmic reticulum (ER) lead to an ER stress response. Prolonged ER stress may lead to cell death. Glucose‐regulated protein (GRP) 78 (Bip) is an ER lumen protein whose expression is induced during ER stress. GRP78 is involved in polypeptide translocation across the ER membrane, and also acts as an apoptotic regulator by protecting the host cell against ER stress‐induced cell death, although the mechanism by which GRP78 exerts its cytoprotective effect is not understood. The present study was carried out to determine whether one of the mechanisms of cell death inhibition by GRP78 involves inhibition of caspase activation. Our studies indicate that treatment of cells with ER stress inducers causes GRP78 to redistribute from the ER lumen with subpopulations existing in the cytosol and as an ER transmembrane protein. GRP78 inhibits cytochrome c ‐mediated caspase activation in a cell‐free system, and expression of GRP78 blocks both caspase activation and caspase‐mediated cell death. GRP78 forms a complex with caspase‐7 and ‐12 and prevents release of caspase‐12 from the ER. Addition of (d)ATP dissociates this complex and may facilitate movement of caspase‐12 into the cytoplasm to set in motion the cytosolic component of the ER stress‐induced apoptotic cascade. These results define a novel protective role for GRP78 in preventing ER stress‐induced cell death." @default.
• W2104790095 created "2016-06-24" @default.
• W2104790095 creator A5001981668 @default.
• W2104790095 creator A5005404981 @default.
• W2104790095 creator A5007520181 @default.
• W2104790095 creator A5017960026 @default.
• W2104790095 creator A5019807837 @default.
• W2104790095 creator A5043919479 @default.
• W2104790095 creator A5055507392 @default.
• W2104790095 creator A5062616982 @default.
• W2104790095 creator A5064873628 @default.
• W2104790095 creator A5077480819 @default.
• W2104790095 date "2002-02-01" @default.
• W2104790095 modified "2023-10-14" @default.
• W2104790095 title "Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78" @default.
• W2104790095 cites W1506642042 @default.
• W2104790095 cites W1515506492 @default.
• W2104790095 cites W1587050401 @default.
• W2104790095 cites W1633538413 @default.
• W2104790095 cites W1966996818 @default.
• W2104790095 cites W1970182526 @default.
• W2104790095 cites W1976675239 @default.
• W2104790095 cites W1981106016 @default.
• W2104790095 cites W1985339713 @default.
• W2104790095 cites W1985896963 @default.
• W2104790095 cites W1996785364 @default.
• W2104790095 cites W1998154566 @default.
• W2104790095 cites W2002439304 @default.
• W2104790095 cites W2013309566 @default.
• W2104790095 cites W2013486761 @default.
• W2104790095 cites W2025229617 @default.
• W2104790095 cites W2031418855 @default.
• W2104790095 cites W2033876617 @default.
• W2104790095 cites W2034213169 @default.
• W2104790095 cites W2036734671 @default.
• W2104790095 cites W2039386747 @default.
• W2104790095 cites W2049876394 @default.
• W2104790095 cites W2063826476 @default.
• W2104790095 cites W2067701929 @default.
• W2104790095 cites W2070715459 @default.
• W2104790095 cites W2075761806 @default.
• W2104790095 cites W2075769701 @default.
• W2104790095 cites W2081868777 @default.
• W2104790095 cites W2094478098 @default.
• W2104790095 cites W2107601804 @default.
• W2104790095 cites W2107789276 @default.
• W2104790095 cites W2117074998 @default.
• W2104790095 cites W2117998622 @default.
• W2104790095 cites W2119683782 @default.
• W2104790095 cites W2120939161 @default.
• W2104790095 cites W2133425838 @default.
• W2104790095 cites W2157999078 @default.
• W2104790095 cites W2168820134 @default.
• W2104790095 cites W2192080449 @default.
• W2104790095 doi "https://doi.org/10.1016/s0014-5793(02)02289-5" @default.
• W2104790095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3971841" @default.
• W2104790095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11943137" @default.
• W2104790095 hasPublicationYear "2002" @default.
• W2104790095 type Work @default.
• W2104790095 sameAs 2104790095 @default.
• W2104790095 citedByCount "525" @default.
• W2104790095 countsByYear W21047900952012 @default.
• W2104790095 countsByYear W21047900952013 @default.
• W2104790095 countsByYear W21047900952014 @default.
• W2104790095 countsByYear W21047900952015 @default.
• W2104790095 countsByYear W21047900952016 @default.
• W2104790095 countsByYear W21047900952017 @default.
• W2104790095 countsByYear W21047900952018 @default.
• W2104790095 countsByYear W21047900952019 @default.
• W2104790095 countsByYear W21047900952020 @default.
• W2104790095 countsByYear W21047900952021 @default.
• W2104790095 countsByYear W21047900952022 @default.
• W2104790095 countsByYear W21047900952023 @default.
• W2104790095 crossrefType "journal-article" @default.
• W2104790095 hasAuthorship W2104790095A5001981668 @default.
• W2104790095 hasAuthorship W2104790095A5005404981 @default.
• W2104790095 hasAuthorship W2104790095A5007520181 @default.
• W2104790095 hasAuthorship W2104790095A5017960026 @default.
• W2104790095 hasAuthorship W2104790095A5019807837 @default.
• W2104790095 hasAuthorship W2104790095A5043919479 @default.
• W2104790095 hasAuthorship W2104790095A5055507392 @default.
• W2104790095 hasAuthorship W2104790095A5062616982 @default.
• W2104790095 hasAuthorship W2104790095A5064873628 @default.
• W2104790095 hasAuthorship W2104790095A5077480819 @default.
• W2104790095 hasBestOaLocation W21047900951 @default.
• W2104790095 hasConcept C139447449 @default.
• W2104790095 hasConcept C158617107 @default.
• W2104790095 hasConcept C181199279 @default.
• W2104790095 hasConcept C185592680 @default.
• W2104790095 hasConcept C190283241 @default.
• W2104790095 hasConcept C2780292996 @default.
• W2104790095 hasConcept C31573885 @default.
• W2104790095 hasConcept C55493867 @default.
• W2104790095 hasConcept C86803240 @default.
• W2104790095 hasConcept C95444343 @default.
• W2104790095 hasConcept C98424977 @default.
• W2104790095 hasConcept C98539663 @default.
• W2104790095 hasConceptScore W2104790095C139447449 @default.

• next