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• W2104794787 abstract "Despite the numerous reports on the role of tumor necrosis factor-alpha (TNF-alpha) in the brain neuropathology, very little is known about the mechanisms by which TNF-alpha may mediate neuroprotection. Different hypotheses pertain to the molecular and cellular effectors triggered by the activation of TNF receptors (TNFRI and TNFR2). They are focused on diminishing the production of nitric oxide and free radicals, alteration of excitatory amino acids neurotransmission, maintenance of neuronal calcium homeostasis and induction of neurotrophic factors synthesis. In this review all these data are summarized. Moreover, possible explanations for the inconsistent data concerning the TNF-alpha effect on neuron are discussed." @default.
• W2104794787 created "2016-06-24" @default.
• W2104794787 creator A5060480882 @default.
• W2104794787 date "2008-01-01" @default.
• W2104794787 modified "2023-09-23" @default.
• W2104794787 title "Pro-inflammatory cytokine TNF-alpha as a neuroprotective agent in the brain." @default.
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