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- W2104804511 endingPage "a019794" @default.
- W2104804511 startingPage "a019794" @default.
- W2104804511 abstract "Fungi are adept at changing their cell shape and developmental program in response to signals in their surroundings. Here we focus on a group of evolutionarily related fungal pathogens of humans known as the thermally dimorphic fungi. These organisms grow in a hyphal form in the environment but shift their morphology drastically within a mammalian host. Temperature is one of the main host signals that initiates their conversion to the host form and is sufficient in the laboratory to trigger establishment of this host-adapted developmental program. Here we discuss the major human pathogens in this group, which are Blastomyces dermatiditis, Coccidioides immitis/posadasii, Histoplasma capsulatum, Paracoccidioides brasiliensis/lutzii, Sporothrix schenckii, and Talaromyces marneffei (formerly known as Penicillium marneffei). The majority of these organisms are primary pathogens, with the ability to cause disease in healthy humans who encounter them in endemic areas." @default.
- W2104804511 created "2016-06-24" @default.
- W2104804511 creator A5023498470 @default.
- W2104804511 creator A5049808247 @default.
- W2104804511 date "2014-11-10" @default.
- W2104804511 modified "2023-10-16" @default.
- W2104804511 title "Thermally Dimorphic Human Fungal Pathogens—Polyphyletic Pathogens with a Convergent Pathogenicity Trait" @default.
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