FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104804571> ?p ?o ?g. }

• W2104804571 endingPage "1701" @default.
• W2104804571 startingPage "1694" @default.
• W2104804571 abstract "Summary Background and objectives Inhibition of the renin-angiotensin-aldosterone system decreases proteinuria and slows estimated GFR decline in patients with type 2 diabetes mellitus with overt nephropathy. Serum aldosterone levels may increase during renin-angiotensin-aldosterone system blockade. The determinants and consequences of this aldosterone breakthrough remain unknown. Design, setting, participants, & measurements This study examined the incidence, determinants, and changes associated with aldosterone breakthrough in a posthoc analysis of a randomized study that compared the effect of two angiotensin II receptor blockers in patients with type 2 diabetes mellitus with overt nephropathy. Results Of 567 of 860 participants included in this posthoc analysis, 28% of participants developed aldosterone breakthrough, which was defined by an increase greater than 10% over baseline values of serum aldosterone levels after 1 year of angiotensin II receptor blocker treatment. Factors independently associated with aldosterone breakthrough at 1 year were lower serum aldosterone and potassium levels at baseline, higher decreases in sodium intake, systolic BP, and estimated GFR from baseline to 1 year, and use of losartan versus telmisartan. Aldosterone breakthrough at 6 months was not sustained at 1 year in 69% of cases, and it did not predict estimated GFR decrease and proteinuria increase between 6 months and 1 year. Conclusions Aldosterone breakthrough is a frequent event 1 year after initiating renin-angiotensin-aldosterone system blockade, particularly in participants exposed to intensive lowering of BP with sodium depletion and short-acting angiotensin II receptor blockers. Short-term serum aldosterone level increases at 6 months are not associated with negative kidney outcomes between 6 months and 1 year." @default.
• W2104804571 created "2016-06-24" @default.
• W2104804571 creator A5012514694 @default.
• W2104804571 creator A5021262573 @default.
• W2104804571 creator A5057949907 @default.
• W2104804571 creator A5080660015 @default.
• W2104804571 creator A5087896662 @default.
• W2104804571 creator A5088282906 @default.
• W2104804571 date "2013-10-01" @default.
• W2104804571 modified "2023-10-18" @default.
• W2104804571 title "Determinants and Changes Associated with Aldosterone Breakthrough after Angiotensin II Receptor Blockade in Patients with Type 2 Diabetes with Overt Nephropathy" @default.
• W2104804571 cites W1528229609 @default.
• W2104804571 cites W1965227811 @default.
• W2104804571 cites W1967872067 @default.
• W2104804571 cites W1976167638 @default.
• W2104804571 cites W1993725103 @default.
• W2104804571 cites W2000060059 @default.
• W2104804571 cites W2010799694 @default.
• W2104804571 cites W2017268330 @default.
• W2104804571 cites W2044773944 @default.
• W2104804571 cites W2056976690 @default.
• W2104804571 cites W2057886201 @default.
• W2104804571 cites W2066051647 @default.
• W2104804571 cites W2072543770 @default.
• W2104804571 cites W2073062706 @default.
• W2104804571 cites W2089034838 @default.
• W2104804571 cites W2102519244 @default.
• W2104804571 cites W2110418992 @default.
• W2104804571 cites W2118207258 @default.
• W2104804571 cites W2119950421 @default.
• W2104804571 cites W2124737750 @default.
• W2104804571 cites W2135856179 @default.
• W2104804571 cites W2137177722 @default.
• W2104804571 cites W2153585291 @default.
• W2104804571 cites W2156825907 @default.
• W2104804571 cites W2162970447 @default.
• W2104804571 cites W2163709605 @default.
• W2104804571 cites W2164802857 @default.
• W2104804571 cites W2170453602 @default.
• W2104804571 cites W2171682550 @default.
• W2104804571 cites W2615684303 @default.
• W2104804571 doi "https://doi.org/10.2215/cjn.06960712" @default.
• W2104804571 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3789346" @default.
• W2104804571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23929924" @default.
• W2104804571 hasPublicationYear "2013" @default.
• W2104804571 type Work @default.
• W2104804571 sameAs 2104804571 @default.
• W2104804571 citedByCount "30" @default.
• W2104804571 countsByYear W21048045712013 @default.
• W2104804571 countsByYear W21048045712014 @default.
• W2104804571 countsByYear W21048045712015 @default.
• W2104804571 countsByYear W21048045712016 @default.
• W2104804571 countsByYear W21048045712017 @default.
• W2104804571 countsByYear W21048045712018 @default.
• W2104804571 countsByYear W21048045712019 @default.
• W2104804571 countsByYear W21048045712020 @default.
• W2104804571 countsByYear W21048045712022 @default.
• W2104804571 crossrefType "journal-article" @default.
• W2104804571 hasAuthorship W2104804571A5012514694 @default.
• W2104804571 hasAuthorship W2104804571A5021262573 @default.
• W2104804571 hasAuthorship W2104804571A5057949907 @default.
• W2104804571 hasAuthorship W2104804571A5080660015 @default.
• W2104804571 hasAuthorship W2104804571A5087896662 @default.
• W2104804571 hasAuthorship W2104804571A5088282906 @default.
• W2104804571 hasBestOaLocation W21048045711 @default.
• W2104804571 hasConcept C104849204 @default.
• W2104804571 hasConcept C123915805 @default.
• W2104804571 hasConcept C126322002 @default.
• W2104804571 hasConcept C134018914 @default.
• W2104804571 hasConcept C138976137 @default.
• W2104804571 hasConcept C198710026 @default.
• W2104804571 hasConcept C2778525890 @default.
• W2104804571 hasConcept C2779561371 @default.
• W2104804571 hasConcept C2779716603 @default.
• W2104804571 hasConcept C2779922275 @default.
• W2104804571 hasConcept C2780091579 @default.
• W2104804571 hasConcept C2780288358 @default.
• W2104804571 hasConcept C2781184683 @default.
• W2104804571 hasConcept C2908929049 @default.
• W2104804571 hasConcept C2909209853 @default.
• W2104804571 hasConcept C555293320 @default.
• W2104804571 hasConcept C71924100 @default.
• W2104804571 hasConcept C84393581 @default.
• W2104804571 hasConceptScore W2104804571C104849204 @default.
• W2104804571 hasConceptScore W2104804571C123915805 @default.
• W2104804571 hasConceptScore W2104804571C126322002 @default.
• W2104804571 hasConceptScore W2104804571C134018914 @default.
• W2104804571 hasConceptScore W2104804571C138976137 @default.
• W2104804571 hasConceptScore W2104804571C198710026 @default.
• W2104804571 hasConceptScore W2104804571C2778525890 @default.
• W2104804571 hasConceptScore W2104804571C2779561371 @default.
• W2104804571 hasConceptScore W2104804571C2779716603 @default.
• W2104804571 hasConceptScore W2104804571C2779922275 @default.
• W2104804571 hasConceptScore W2104804571C2780091579 @default.
• W2104804571 hasConceptScore W2104804571C2780288358 @default.
• W2104804571 hasConceptScore W2104804571C2781184683 @default.
• W2104804571 hasConceptScore W2104804571C2908929049 @default.
• W2104804571 hasConceptScore W2104804571C2909209853 @default.

• next