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- W2104810144 abstract "The pharmacological activity of polyphenolic silibinin from milk thistle (Silybum marianum) is primarily due to its antioxidant property. However, this study found that silibinin promoted sustained superoxide (O(2)(.-)) production that was specifically scavenged by exogenous superoxide dismutase (SOD) in MCF-7 cells, while the activity of endogenous SOD was not changed by silibinin. Previous work proved that silibinin induced MCF-7 cell apoptosis through mitochondrial pathway and this study further proved that O(2)(.-) generation induced by silibinin was also related to mitochondria. It was found that respiratory chain complexes I, II and III were all involved in silibinin-induced O(2)(.-) generation. Moreover, it was found that silibinin-induced O(2)(.-) had protective effect, as exogenous SOD markedly enhanced silibinin-induced apoptosis." @default.
- W2104810144 created "2016-06-24" @default.
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- W2104810144 date "2009-12-08" @default.
- W2104810144 modified "2023-09-25" @default.
- W2104810144 title "Silibinin induces protective superoxide generation in human breast cancer MCF-7 cells" @default.
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- W2104810144 doi "https://doi.org/10.3109/10715760903300717" @default.
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