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• W2104828227 abstract "To examine the relationship between folding and export competence by the twin-arginine translocation (Tat) pathway we analyzed the subcellular localization of fusions between a set of eight putative Tat leader peptides and alkaline phosphatase in isogenic Escherichia coli strains that either allow or disfavor the formation of protein disulfide bonds in the cytoplasm. We show that export by the Tat translocator is observed only in strains that enable oxidative protein folding in the cytoplasm. Further, we show that other disulfide-containing proteins, namely single-chain Fv and heterodimeric F(AB) antibody fragments, are export-competent only in strains having an oxidizing cytoplasm. Functional, heterodimeric F(AB) protein was exported from the cytoplasm by means of a Tat leader peptide fused to the heavy chain alone, indicating that the formation of a disulfide-bonded dimer preceeds export. These results demonstrate that in vivo only proteins that have attained the native conformation are exported by the Tat translocator, indicating that a folding quality-control mechanism is intrinsic to the export process. The ability to export proteins with disulfide bonds and the folding proofing feature of the Tat pathway are of interest for biotechnology applications." @default.
• W2104828227 created "2016-06-24" @default.
• W2104828227 creator A5006359444 @default.
• W2104828227 creator A5047788420 @default.
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• W2104828227 date "2003-04-29" @default.
• W2104828227 modified "2023-09-30" @default.
• W2104828227 title "Folding quality control in the export of proteins by the bacterial twin-arginine translocation pathway" @default.
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• W2104828227 doi "https://doi.org/10.1073/pnas.0937838100" @default.
• W2104828227 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/156335" @default.
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• W2104828227 hasPublicationYear "2003" @default.
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