FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104829672> ?p ?o ?g. }

• W2104829672 endingPage "4636" @default.
• W2104829672 startingPage "4630" @default.
• W2104829672 abstract "The immunosuppressive cytokine IL-10 is associated with poor prognosis in colon cancer. Although macrophages are involved in antitumor defenses, production of IL-10 by tumor cells may permit malignant cells escape to cell-mediated immune defenses. To investigate interactions between macrophages and tumor cells in humans, we cultured macrophages isolated from patients and tested the effect of these macrophages on the production of IL-10 by several tumor cell lines. Macrophages were isolated from pleural effusions of patients with malignancy and from noncancer control patients. We demonstrated that culture supernatants of macrophages from both sources strongly stimulated IL-10 production by the three different human colon adenocarcinoma cell lines, Colo 205, Colo 320, and HT29. Recombinant IL-6, but not IL-10, TNF-alpha, and IFN-alpha, stimulated the secretion of IL-10 by colon tumor cells. mAbs against IL-6 and IL-6R prevented the effect of macrophage culture supernatants and of rIL-6, respectively, on the production of IL-10 by the three cell lines. Cocultures of macrophages and colon cancer cells showed that these tumor cells first stimulated macrophages to produce IL-6, which was then followed by IL-6-induced IL-10 production by colon cancer cells. Finally, we showed that IL-10 gene regulation was mediated by STAT3, which was phosphorylated after the binding of IL-6 to IL-6R. This is the first demonstration that IL-6, secreted by macrophages, can induce a STAT3-mediated IL-10 production by colon tumor cells." @default.
• W2104829672 created "2016-06-24" @default.
• W2104829672 creator A5003638462 @default.
• W2104829672 creator A5030796777 @default.
• W2104829672 creator A5072544785 @default.
• W2104829672 creator A5081372199 @default.
• W2104829672 creator A5085858117 @default.
• W2104829672 date "2004-04-01" @default.
• W2104829672 modified "2023-10-16" @default.
• W2104829672 title "Recruitment of STAT3 for Production of IL-10 by Colon Carcinoma Cells Induced by Macrophage-Derived IL-6" @default.
• W2104829672 cites W1495457417 @default.
• W2104829672 cites W1517987530 @default.
• W2104829672 cites W1562490575 @default.
• W2104829672 cites W1591670144 @default.
• W2104829672 cites W171868807 @default.
• W2104829672 cites W1942879517 @default.
• W2104829672 cites W1966948292 @default.
• W2104829672 cites W1974728282 @default.
• W2104829672 cites W1976434580 @default.
• W2104829672 cites W1981799488 @default.
• W2104829672 cites W1984455580 @default.
• W2104829672 cites W1990268597 @default.
• W2104829672 cites W1991503430 @default.
• W2104829672 cites W1992537683 @default.
• W2104829672 cites W1995997868 @default.
• W2104829672 cites W1997715513 @default.
• W2104829672 cites W2002776738 @default.
• W2104829672 cites W2009936687 @default.
• W2104829672 cites W2032598213 @default.
• W2104829672 cites W2032999541 @default.
• W2104829672 cites W2034875428 @default.
• W2104829672 cites W2038780899 @default.
• W2104829672 cites W2048407755 @default.
• W2104829672 cites W2071227948 @default.
• W2104829672 cites W2074243608 @default.
• W2104829672 cites W2088357471 @default.
• W2104829672 cites W2107334931 @default.
• W2104829672 cites W2108334344 @default.
• W2104829672 cites W2111034338 @default.
• W2104829672 cites W2123118712 @default.
• W2104829672 cites W2150176853 @default.
• W2104829672 cites W2151950129 @default.
• W2104829672 cites W2156075902 @default.
• W2104829672 cites W2289177026 @default.
• W2104829672 cites W4300339315 @default.
• W2104829672 doi "https://doi.org/10.4049/jimmunol.172.7.4630" @default.
• W2104829672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15034082" @default.
• W2104829672 hasPublicationYear "2004" @default.
• W2104829672 type Work @default.
• W2104829672 sameAs 2104829672 @default.
• W2104829672 citedByCount "101" @default.
• W2104829672 countsByYear W21048296722012 @default.
• W2104829672 countsByYear W21048296722013 @default.
• W2104829672 countsByYear W21048296722014 @default.
• W2104829672 countsByYear W21048296722015 @default.
• W2104829672 countsByYear W21048296722016 @default.
• W2104829672 countsByYear W21048296722017 @default.
• W2104829672 countsByYear W21048296722018 @default.
• W2104829672 countsByYear W21048296722019 @default.
• W2104829672 countsByYear W21048296722020 @default.
• W2104829672 countsByYear W21048296722021 @default.
• W2104829672 countsByYear W21048296722022 @default.
• W2104829672 countsByYear W21048296722023 @default.
• W2104829672 crossrefType "journal-article" @default.
• W2104829672 hasAuthorship W2104829672A5003638462 @default.
• W2104829672 hasAuthorship W2104829672A5030796777 @default.
• W2104829672 hasAuthorship W2104829672A5072544785 @default.
• W2104829672 hasAuthorship W2104829672A5081372199 @default.
• W2104829672 hasAuthorship W2104829672A5085858117 @default.
• W2104829672 hasBestOaLocation W21048296721 @default.
• W2104829672 hasConcept C134018914 @default.
• W2104829672 hasConcept C17991360 @default.
• W2104829672 hasConcept C202751555 @default.
• W2104829672 hasConcept C203014093 @default.
• W2104829672 hasConcept C2778690821 @default.
• W2104829672 hasConcept C2779244956 @default.
• W2104829672 hasConcept C49039625 @default.
• W2104829672 hasConcept C502942594 @default.
• W2104829672 hasConcept C54355233 @default.
• W2104829672 hasConcept C55493867 @default.
• W2104829672 hasConcept C81885089 @default.
• W2104829672 hasConcept C86803240 @default.
• W2104829672 hasConceptScore W2104829672C134018914 @default.
• W2104829672 hasConceptScore W2104829672C17991360 @default.
• W2104829672 hasConceptScore W2104829672C202751555 @default.
• W2104829672 hasConceptScore W2104829672C203014093 @default.
• W2104829672 hasConceptScore W2104829672C2778690821 @default.
• W2104829672 hasConceptScore W2104829672C2779244956 @default.
• W2104829672 hasConceptScore W2104829672C49039625 @default.
• W2104829672 hasConceptScore W2104829672C502942594 @default.
• W2104829672 hasConceptScore W2104829672C54355233 @default.
• W2104829672 hasConceptScore W2104829672C55493867 @default.
• W2104829672 hasConceptScore W2104829672C81885089 @default.
• W2104829672 hasConceptScore W2104829672C86803240 @default.
• W2104829672 hasIssue "7" @default.
• W2104829672 hasLocation W21048296721 @default.
• W2104829672 hasLocation W21048296722 @default.
• W2104829672 hasOpenAccess W2104829672 @default.

• next