FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104832885> ?p ?o ?g. }

• W2104832885 endingPage "1207" @default.
• W2104832885 startingPage "1195" @default.
• W2104832885 abstract "ABSTRACT In gram-negative organisms, high-affinity transport of iron substrates requires energy transduction to specific outer membrane receptors by the TonB-ExbB-ExbD complex. Vibrio cholerae encodes two TonB proteins, one of which, TonB1, recognizes only a subset of V . cholerae TonB-dependent receptors and does not facilitate transport through Escherichia coli receptors. To investigate the receptor specificity exhibited by V . cholerae TonB1, chimeras were created between V . cholerae TonB1 and E . coli TonB. The activities of the chimeric TonB proteins in iron utilization assays demonstrated that the C-terminal one-third of either TonB confers the receptor specificities associated with the full-length TonB. Single-amino-acid substitutions near the C terminus of V . cholerae TonB1 were identified that allowed TonB1 to recognize E . coli receptors and at least one V . cholerae TonB2-dependent receptor. This indicates that the very C-terminal end of V . cholerae TonB1 determines receptor specificity. The regions of the TonB-dependent receptors involved in specificity for a particular TonB protein were investigated in experiments involving domain switching between V . cholerae and E . coli receptors exhibiting different TonB specificities. Switching the conserved TonB box heptapeptides at the N termini of these receptors did not alter their TonB specificities. However, replacing the amino acid immediately preceding the TonB box in E . coli receptors with an aromatic residue allowed these receptors to use V . cholerae TonB1. Further, site-directed mutagenesis of the TonB box −1 residue in a V . cholerae TonB2-dependent receptor demonstrated that a large hydrophobic amino acid in this position promotes recognition of V . cholerae TonB1. These data suggest that the TonB box −1 position controls productive interactions with V . cholerae TonB1." @default.
• W2104832885 created "2016-06-24" @default.
• W2104832885 creator A5024658417 @default.
• W2104832885 creator A5060659632 @default.
• W2104832885 date "2003-02-15" @default.
• W2104832885 modified "2023-10-14" @default.
• W2104832885 title "Analysis of Residues Determining Specificity of <i>Vibrio cholerae</i> TonB1 for Its Receptors" @default.
• W2104832885 cites W1487899918 @default.
• W2104832885 cites W1495533261 @default.
• W2104832885 cites W1540348039 @default.
• W2104832885 cites W1545762144 @default.
• W2104832885 cites W1558837374 @default.
• W2104832885 cites W1568088229 @default.
• W2104832885 cites W1578241902 @default.
• W2104832885 cites W1580903801 @default.
• W2104832885 cites W1587329961 @default.
• W2104832885 cites W1594494428 @default.
• W2104832885 cites W1597690320 @default.
• W2104832885 cites W163411833 @default.
• W2104832885 cites W1747389599 @default.
• W2104832885 cites W1751864398 @default.
• W2104832885 cites W1787690277 @default.
• W2104832885 cites W1912992879 @default.
• W2104832885 cites W1943555456 @default.
• W2104832885 cites W1965600386 @default.
• W2104832885 cites W1990163323 @default.
• W2104832885 cites W1992634919 @default.
• W2104832885 cites W1997417152 @default.
• W2104832885 cites W2006580038 @default.
• W2104832885 cites W2014590482 @default.
• W2104832885 cites W2031534307 @default.
• W2104832885 cites W2031546705 @default.
• W2104832885 cites W2033536956 @default.
• W2104832885 cites W2038795589 @default.
• W2104832885 cites W2042263448 @default.
• W2104832885 cites W2054941036 @default.
• W2104832885 cites W2060472654 @default.
• W2104832885 cites W2060913542 @default.
• W2104832885 cites W2061527369 @default.
• W2104832885 cites W2065885424 @default.
• W2104832885 cites W2080102616 @default.
• W2104832885 cites W2084608838 @default.
• W2104832885 cites W2098162203 @default.
• W2104832885 cites W2100837269 @default.
• W2104832885 cites W2101820146 @default.
• W2104832885 cites W2102319161 @default.
• W2104832885 cites W2107656569 @default.
• W2104832885 cites W2108623931 @default.
• W2104832885 cites W2113480767 @default.
• W2104832885 cites W2115511385 @default.
• W2104832885 cites W2116910915 @default.
• W2104832885 cites W2120816623 @default.
• W2104832885 cites W2122400865 @default.
• W2104832885 cites W2129319357 @default.
• W2104832885 cites W2132417094 @default.
• W2104832885 cites W2141653906 @default.
• W2104832885 cites W2141848152 @default.
• W2104832885 cites W2144474352 @default.
• W2104832885 cites W2144621559 @default.
• W2104832885 cites W2146760203 @default.
• W2104832885 cites W2157498391 @default.
• W2104832885 cites W2169540382 @default.
• W2104832885 doi "https://doi.org/10.1128/jb.185.4.1195-1207.2003" @default.
• W2104832885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/142855" @default.
• W2104832885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12562789" @default.
• W2104832885 hasPublicationYear "2003" @default.
• W2104832885 type Work @default.
• W2104832885 sameAs 2104832885 @default.
• W2104832885 citedByCount "25" @default.
• W2104832885 countsByYear W21048328852012 @default.
• W2104832885 countsByYear W21048328852013 @default.
• W2104832885 countsByYear W21048328852014 @default.
• W2104832885 countsByYear W21048328852015 @default.
• W2104832885 countsByYear W21048328852016 @default.
• W2104832885 countsByYear W21048328852017 @default.
• W2104832885 countsByYear W21048328852022 @default.
• W2104832885 crossrefType "journal-article" @default.
• W2104832885 hasAuthorship W2104832885A5024658417 @default.
• W2104832885 hasAuthorship W2104832885A5060659632 @default.
• W2104832885 hasBestOaLocation W21048328851 @default.
• W2104832885 hasConcept C104317684 @default.
• W2104832885 hasConcept C146587185 @default.
• W2104832885 hasConcept C170493617 @default.
• W2104832885 hasConcept C2778643871 @default.
• W2104832885 hasConcept C523546767 @default.
• W2104832885 hasConcept C54355233 @default.
• W2104832885 hasConcept C547475151 @default.
• W2104832885 hasConcept C55493867 @default.
• W2104832885 hasConcept C86803240 @default.
• W2104832885 hasConcept C89423630 @default.
• W2104832885 hasConceptScore W2104832885C104317684 @default.
• W2104832885 hasConceptScore W2104832885C146587185 @default.
• W2104832885 hasConceptScore W2104832885C170493617 @default.
• W2104832885 hasConceptScore W2104832885C2778643871 @default.
• W2104832885 hasConceptScore W2104832885C523546767 @default.
• W2104832885 hasConceptScore W2104832885C54355233 @default.
• W2104832885 hasConceptScore W2104832885C547475151 @default.
• W2104832885 hasConceptScore W2104832885C55493867 @default.

• next