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• W2104847180 abstract "A series of racemic N-arylalkyl-2-azaadamantan-1-ols (9–15) and the corresponding deoxygenated, achiral N-arylalkyl-2-azaadamantanes (23–29) were synthesized and screened in competition binding assays against a panel of CNS targets. Adamantyl hemiaminals 9–15 displayed generally low affinity for both σ1 (Ki values = 294–1950 nM) and σ2 receptors (Ki values = 201–1020 nM), and negligible affinity for 42 other CNS proteins. Deoxygenation of 9–15 to give the corresponding achiral azaadamantanes 23–29 greatly improved affinity for σ1 (Ki values = 8.3–239 nM) and σ2 receptors (Ki values = 34–312 nM)." @default.
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• W2104847180 date "2011-09-01" @default.
• W2104847180 modified "2023-09-24" @default.
• W2104847180 title "N-Arylalkyl-2-azaadamantanes as cage-expanded polycarbocyclic sigma (σ) receptor ligands" @default.
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• W2104847180 doi "https://doi.org/10.1016/j.bmcl.2011.07.028" @default.
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