FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104868424> ?p ?o ?g. }

• W2104868424 endingPage "405" @default.
• W2104868424 startingPage "405" @default.
• W2104868424 abstract "Boar taint is a major obstacle when using uncastrated male pigs for swine production. One of the main compounds causing this taint is androstenone, a pheromone produced in porcine testis. Here we use microarrays to study the expression of thousands of genes simultaneously in testis of high and low androstenone boars. The study allows identification of genes and pathways associated with elevated androstenone levels, which is essential for recognising potential molecular markers for breeding purposes.Testicular tissue was collected from 60 boars, 30 with extreme high and 30 with extreme low levels of androstenone, from each of the two breeds Duroc and Norwegian Landrace. The samples were hybridised to porcine arrays containing 26,877 cDNA clones, detecting 563 and 160 genes that were differentially expressed (p < 0.01) in Duroc and Norwegian Landrace, respectively. Of these significantly up- and down-regulated clones, 72 were found to be common for the two breeds, suggesting the possibility of both general and breed specific mechanisms in regulation of, or response to androstenone levels in boars. Ten genes were chosen for verification of expression patterns by quantitative real competitive PCR and real-time PCR. As expected, our results point towards steroid hormone metabolism and biosynthesis as important biological processes for the androstenone levels, but other potential pathways were identified as well. Among these were oxidoreductase activity, ferric iron binding, iron ion binding and electron transport activities. Genes belonging to the cytochrome P450 and hydroxysteroid dehydrogenase families were highly up-regulated, in addition to several genes encoding different families of conjugation enzymes. Furthermore, a number of genes encoding transcription factors were found both up- and down-regulated. The high number of clones belonging to ferric iron and iron ion binding suggests an importance of these genes, and the association between these pathways and androstenone levels is not previously described.This study contributes to the understanding of the complex genetic system controlling and responding to androstenone levels in pig testis. The identification of new pathways and genes involved in the biosynthesis and metabolism of androstenone is an important first step towards finding molecular markers to reduce boar taint." @default.
• W2104868424 created "2016-06-24" @default.
• W2104868424 creator A5003226940 @default.
• W2104868424 creator A5007101652 @default.
• W2104868424 creator A5047000286 @default.
• W2104868424 creator A5053585785 @default.
• W2104868424 creator A5066069950 @default.
• W2104868424 creator A5076934232 @default.
• W2104868424 creator A5085842865 @default.
• W2104868424 creator A5090367243 @default.
• W2104868424 creator A5091206593 @default.
• W2104868424 date "2007-01-01" @default.
• W2104868424 modified "2023-10-13" @default.
• W2104868424 title "Gene expression profiles in testis of pigs with extreme high and low levels of androstenone" @default.
• W2104868424 cites W105949446 @default.
• W2104868424 cites W1499968189 @default.
• W2104868424 cites W1506758067 @default.
• W2104868424 cites W1525342509 @default.
• W2104868424 cites W1533335653 @default.
• W2104868424 cites W1543641272 @default.
• W2104868424 cites W1546952499 @default.
• W2104868424 cites W1586778421 @default.
• W2104868424 cites W1604336286 @default.
• W2104868424 cites W1748127419 @default.
• W2104868424 cites W178032987 @default.
• W2104868424 cites W1857150820 @default.
• W2104868424 cites W1924733673 @default.
• W2104868424 cites W195732308 @default.
• W2104868424 cites W1963688752 @default.
• W2104868424 cites W1966165147 @default.
• W2104868424 cites W1968422513 @default.
• W2104868424 cites W1969761972 @default.
• W2104868424 cites W1973433961 @default.
• W2104868424 cites W1974733729 @default.
• W2104868424 cites W1977442791 @default.
• W2104868424 cites W1979833417 @default.
• W2104868424 cites W1987525830 @default.
• W2104868424 cites W1988221004 @default.
• W2104868424 cites W1989350219 @default.
• W2104868424 cites W1990665707 @default.
• W2104868424 cites W1992502163 @default.
• W2104868424 cites W1998841669 @default.
• W2104868424 cites W1999410521 @default.
• W2104868424 cites W2000688167 @default.
• W2104868424 cites W2002951812 @default.
• W2104868424 cites W2003432885 @default.
• W2104868424 cites W200391904 @default.
• W2104868424 cites W2005013286 @default.
• W2104868424 cites W2009443375 @default.
• W2104868424 cites W2012865087 @default.
• W2104868424 cites W2013444425 @default.
• W2104868424 cites W2014732454 @default.
• W2104868424 cites W2018769428 @default.
• W2104868424 cites W2020490816 @default.
• W2104868424 cites W2025055522 @default.
• W2104868424 cites W2025202132 @default.
• W2104868424 cites W2025679749 @default.
• W2104868424 cites W2027816981 @default.
• W2104868424 cites W2027851452 @default.
• W2104868424 cites W2028365601 @default.
• W2104868424 cites W2029157226 @default.
• W2104868424 cites W2034022021 @default.
• W2104868424 cites W2035892324 @default.
• W2104868424 cites W2039004255 @default.
• W2104868424 cites W2039197774 @default.
• W2104868424 cites W2039332514 @default.
• W2104868424 cites W2041261822 @default.
• W2104868424 cites W2045040068 @default.
• W2104868424 cites W2046405322 @default.
• W2104868424 cites W2047790450 @default.
• W2104868424 cites W2048465228 @default.
• W2104868424 cites W2055182510 @default.
• W2104868424 cites W2055268066 @default.
• W2104868424 cites W2055946879 @default.
• W2104868424 cites W2056844589 @default.
• W2104868424 cites W2059052392 @default.
• W2104868424 cites W2060111464 @default.
• W2104868424 cites W2063353051 @default.
• W2104868424 cites W2063753138 @default.
• W2104868424 cites W2066518128 @default.
• W2104868424 cites W2070312848 @default.
• W2104868424 cites W2071543273 @default.
• W2104868424 cites W2072121992 @default.
• W2104868424 cites W2077213568 @default.
• W2104868424 cites W2077430334 @default.
• W2104868424 cites W2081098333 @default.
• W2104868424 cites W2082043427 @default.
• W2104868424 cites W2086434251 @default.
• W2104868424 cites W2087903408 @default.
• W2104868424 cites W2089501938 @default.
• W2104868424 cites W2091036037 @default.
• W2104868424 cites W2091689326 @default.
• W2104868424 cites W2091894145 @default.
• W2104868424 cites W2099819774 @default.
• W2104868424 cites W2101572590 @default.
• W2104868424 cites W2103075861 @default.
• W2104868424 cites W2104439004 @default.
• W2104868424 cites W2106617991 @default.

• next