Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104869715> ?p ?o ?g. }
- W2104869715 endingPage "146" @default.
- W2104869715 startingPage "125" @default.
- W2104869715 abstract "For many years, it has been suggested that drugs that interfere with dopamine (DA) transmission alter the rewarding impact of primary reinforcers such as food. Research and theory related to the functions of mesolimbic DA are undergoing a substantial conceptual restructuring, with the traditional emphasis on hedonia and primary reward yielding to other concepts and lines of inquiry. The present review is focused upon the involvement of nucleus accumbens DA in effort-related choice behavior. Viewed from the framework of behavioral economics, the effects of accumbens DA depletions and antagonism on food-reinforced behavior are highly dependent upon the work requirements of the instrumental task, and DA-depleted rats show a heightened sensitivity to response costs, especially ratio requirements. Moreover, interference with accumbens DA transmission exerts a powerful influence over effort-related choice behavior. Rats with accumbens DA depletions or antagonism reallocate their instrumental behavior away from food-reinforced tasks that have high response requirements, and show increased selection of low reinforcement/low cost options. Nucleus accumbens DA and adenosine interact in the regulation of effort-related functions, and other brain structures (anterior cingulate cortex, amygdala, ventral pallidum) also are involved. Studies of the brain systems regulating effort-based processes may have implications for understanding drug abuse, as well as symptoms such as psychomotor slowing, fatigue or anergia in depression and other neurological disorders." @default.
- W2104869715 created "2016-06-24" @default.
- W2104869715 creator A5019260923 @default.
- W2104869715 creator A5019481382 @default.
- W2104869715 creator A5033285241 @default.
- W2104869715 creator A5042488292 @default.
- W2104869715 creator A5059365702 @default.
- W2104869715 date "2012-01-01" @default.
- W2104869715 modified "2023-10-18" @default.
- W2104869715 title "THE BEHAVIORAL PHARMACOLOGY OF EFFORT-RELATED CHOICE BEHAVIOR: DOPAMINE, ADENOSINE AND BEYOND" @default.
- W2104869715 cites W113107216 @default.
- W2104869715 cites W119920039 @default.
- W2104869715 cites W1502439265 @default.
- W2104869715 cites W1531245254 @default.
- W2104869715 cites W1556555813 @default.
- W2104869715 cites W1682243858 @default.
- W2104869715 cites W1963623154 @default.
- W2104869715 cites W1964805227 @default.
- W2104869715 cites W1965354593 @default.
- W2104869715 cites W1966891940 @default.
- W2104869715 cites W1967039863 @default.
- W2104869715 cites W1967074973 @default.
- W2104869715 cites W1968191242 @default.
- W2104869715 cites W1969401266 @default.
- W2104869715 cites W1969585350 @default.
- W2104869715 cites W1970575860 @default.
- W2104869715 cites W1971172184 @default.
- W2104869715 cites W1973645400 @default.
- W2104869715 cites W1974343072 @default.
- W2104869715 cites W1974926957 @default.
- W2104869715 cites W1974935656 @default.
- W2104869715 cites W1976129211 @default.
- W2104869715 cites W1976503128 @default.
- W2104869715 cites W1977860908 @default.
- W2104869715 cites W1980678191 @default.
- W2104869715 cites W1982327643 @default.
- W2104869715 cites W1983721187 @default.
- W2104869715 cites W1984673665 @default.
- W2104869715 cites W1985751925 @default.
- W2104869715 cites W1985771124 @default.
- W2104869715 cites W1986685236 @default.
- W2104869715 cites W1987051550 @default.
- W2104869715 cites W1988179423 @default.
- W2104869715 cites W1989103140 @default.
- W2104869715 cites W1989157684 @default.
- W2104869715 cites W1989239787 @default.
- W2104869715 cites W1989637315 @default.
- W2104869715 cites W1989728052 @default.
- W2104869715 cites W1990046088 @default.
- W2104869715 cites W1990517136 @default.
- W2104869715 cites W1992842416 @default.
- W2104869715 cites W1993631201 @default.
- W2104869715 cites W1995339649 @default.
- W2104869715 cites W1997714535 @default.
- W2104869715 cites W1998461664 @default.
- W2104869715 cites W1999209810 @default.
- W2104869715 cites W2000412445 @default.
- W2104869715 cites W2002227836 @default.
- W2104869715 cites W2002321040 @default.
- W2104869715 cites W2003075119 @default.
- W2104869715 cites W2006537215 @default.
- W2104869715 cites W2007497289 @default.
- W2104869715 cites W2007586845 @default.
- W2104869715 cites W2008030855 @default.
- W2104869715 cites W2008921100 @default.
- W2104869715 cites W2009317342 @default.
- W2104869715 cites W2009831159 @default.
- W2104869715 cites W2009875822 @default.
- W2104869715 cites W2010776065 @default.
- W2104869715 cites W2013349633 @default.
- W2104869715 cites W2014536531 @default.
- W2104869715 cites W2015968119 @default.
- W2104869715 cites W2016114488 @default.
- W2104869715 cites W2016130474 @default.
- W2104869715 cites W2018364571 @default.
- W2104869715 cites W2018796355 @default.
- W2104869715 cites W2019506241 @default.
- W2104869715 cites W2019770388 @default.
- W2104869715 cites W2019927998 @default.
- W2104869715 cites W2021834205 @default.
- W2104869715 cites W2022071529 @default.
- W2104869715 cites W2023206850 @default.
- W2104869715 cites W2023732657 @default.
- W2104869715 cites W2024270031 @default.
- W2104869715 cites W2026219855 @default.
- W2104869715 cites W2027124435 @default.
- W2104869715 cites W2029623396 @default.
- W2104869715 cites W2030152049 @default.
- W2104869715 cites W2030459002 @default.
- W2104869715 cites W2030874025 @default.
- W2104869715 cites W2031230566 @default.
- W2104869715 cites W2031570817 @default.
- W2104869715 cites W2031975832 @default.
- W2104869715 cites W2033564079 @default.
- W2104869715 cites W2033582219 @default.
- W2104869715 cites W2034331584 @default.
- W2104869715 cites W2034995598 @default.
- W2104869715 cites W2035064334 @default.