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- W2104872215 abstract "Androgen hormones, the group of steroid hormones, are mailsex hormones. They are vital to numerous physiologicalprocesses including development of mail sex organs andsecondary mail sex characteristics. Beside their normal physi-ologicalfunctions,androgenscanberesponsibleforgrowthandmultiply of malignant cells, or can be cause of some otherdiseases (benign prostate gland hiperthense (BPH), prostategland cancer, brain cancer, breast cancer, acnes, etc.). The factthat the androgens play the key role in many human diseasescauses the intensive investigations in the field of obtaining andapplying antiandrogens. Antiandrogens are substances whichblockade the biological activities of androgens, and because ofthattheyareusedintherapyofsomeandrogen-dependdiseases.In our study of some androstene and adrostane derivatives withpotentional antiandrogenic properties a number of androgeniccompounds were synthesized, structurally analysed and testedfor biologic effects. In this paper our attention was directedtoward the examination of their hydrogen bonding character-istics. Examination of the structures of compounds having highaffinityforandrogenreceptorsledtothesuggestionthatsteroid-receptor binding is primarily the result of interactions betweenthe receptor and the steroidal D ring. Especially, of the greatimportance for the receptor binding are the position and thepossible hydrogen bonds of H-atom from 17β-hydroxyl group.Activity of androgens might be controlled by the A ring and3-oxo or 3-hydroxyl group. As a part of our study, the influ-ences of molecule flexibility and substituents on the structure-activity relationship were also examined. The crystal struc-tures of the compounds were determined by the single crystalX-ray diffraction methods. The energy minimum structureswere obtained by molecular-mechanics calculations." @default.
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- W2104872215 date "2006-08-06" @default.
- W2104872215 modified "2023-10-18" @default.
- W2104872215 title "Hydrogen bonding and structure-activity analysis of some antiandrogens" @default.
- W2104872215 cites W2103727543 @default.
- W2104872215 doi "https://doi.org/10.1107/s0108767306094104" @default.
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