Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104876248> ?p ?o ?g. }
- W2104876248 endingPage "1243" @default.
- W2104876248 startingPage "1231" @default.
- W2104876248 abstract "During vasculogenesis and angiogenesis, endothelial cell responses to growth factors are modulated by the compositional and mechanical properties of a surrounding three-dimensional (3D) extracellular matrix (ECM) that is dominated by either cross-linked fibrin or type I collagen. While 3D-embedded endothelial cells establish adhesive interactions with surrounding ligands to optimally respond to soluble or matrix-bound agonists, the manner in which a randomly ordered ECM with diverse physico-mechanical properties is remodeled to support blood vessel formation has remained undefined. Herein, we demonstrate that endothelial cells initiate neovascularization by unfolding soluble fibronectin (Fn) and depositing a pericellular network of fibrils that serve to support cytoskeletal organization, actomyosin-dependent tension, and the viscoelastic properties of the embedded cells in a 3D-specific fashion. These results advance a new model wherein Fn polymerization serves as a structural scaffolding that displays adhesive ligands on a mechanically ideal substratum for promoting neovessel development." @default.
- W2104876248 created "2016-06-24" @default.
- W2104876248 creator A5003835601 @default.
- W2104876248 creator A5022218689 @default.
- W2104876248 creator A5028618974 @default.
- W2104876248 creator A5037893640 @default.
- W2104876248 creator A5047153331 @default.
- W2104876248 creator A5059736060 @default.
- W2104876248 creator A5060862557 @default.
- W2104876248 creator A5078419333 @default.
- W2104876248 creator A5080476399 @default.
- W2104876248 date "2008-05-01" @default.
- W2104876248 modified "2023-10-18" @default.
- W2104876248 title "Fibronectin fibrillogenesis regulates three-dimensional neovessel formation" @default.
- W2104876248 cites W1515455066 @default.
- W2104876248 cites W1590619267 @default.
- W2104876248 cites W1591280387 @default.
- W2104876248 cites W1964568800 @default.
- W2104876248 cites W1965933207 @default.
- W2104876248 cites W1966765683 @default.
- W2104876248 cites W1967816819 @default.
- W2104876248 cites W1968316337 @default.
- W2104876248 cites W1974170815 @default.
- W2104876248 cites W1985042934 @default.
- W2104876248 cites W1986225001 @default.
- W2104876248 cites W1986574665 @default.
- W2104876248 cites W1992437868 @default.
- W2104876248 cites W2002582091 @default.
- W2104876248 cites W2008414163 @default.
- W2104876248 cites W2009234826 @default.
- W2104876248 cites W2010251891 @default.
- W2104876248 cites W2011217812 @default.
- W2104876248 cites W2013268726 @default.
- W2104876248 cites W2019384293 @default.
- W2104876248 cites W2022326851 @default.
- W2104876248 cites W2023115975 @default.
- W2104876248 cites W2028518884 @default.
- W2104876248 cites W2029351072 @default.
- W2104876248 cites W2031935322 @default.
- W2104876248 cites W2032461554 @default.
- W2104876248 cites W2035422545 @default.
- W2104876248 cites W2038413195 @default.
- W2104876248 cites W2038572636 @default.
- W2104876248 cites W2038963002 @default.
- W2104876248 cites W2040945158 @default.
- W2104876248 cites W2041069947 @default.
- W2104876248 cites W2042162619 @default.
- W2104876248 cites W2045032642 @default.
- W2104876248 cites W2046044320 @default.
- W2104876248 cites W2047470479 @default.
- W2104876248 cites W2050039508 @default.
- W2104876248 cites W2054635074 @default.
- W2104876248 cites W2058096164 @default.
- W2104876248 cites W2058738554 @default.
- W2104876248 cites W2061801043 @default.
- W2104876248 cites W2063753069 @default.
- W2104876248 cites W2063897530 @default.
- W2104876248 cites W2067910961 @default.
- W2104876248 cites W2072743356 @default.
- W2104876248 cites W2073375166 @default.
- W2104876248 cites W2074187493 @default.
- W2104876248 cites W2077090481 @default.
- W2104876248 cites W2081854981 @default.
- W2104876248 cites W2081992432 @default.
- W2104876248 cites W2083216138 @default.
- W2104876248 cites W2083498836 @default.
- W2104876248 cites W2084871901 @default.
- W2104876248 cites W2109088595 @default.
- W2104876248 cites W2109706035 @default.
- W2104876248 cites W2111811045 @default.
- W2104876248 cites W2118837137 @default.
- W2104876248 cites W2119063295 @default.
- W2104876248 cites W2120439608 @default.
- W2104876248 cites W2126527231 @default.
- W2104876248 cites W2128884401 @default.
- W2104876248 cites W2130201056 @default.
- W2104876248 cites W2134208433 @default.
- W2104876248 cites W2139084649 @default.
- W2104876248 cites W2144023435 @default.
- W2104876248 cites W2144026946 @default.
- W2104876248 cites W2146376600 @default.
- W2104876248 cites W2157024197 @default.
- W2104876248 cites W2163989178 @default.
- W2104876248 cites W2168215545 @default.
- W2104876248 cites W2188422153 @default.
- W2104876248 cites W4236861583 @default.
- W2104876248 doi "https://doi.org/10.1101/gad.1643308" @default.
- W2104876248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2335318" @default.
- W2104876248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18451110" @default.
- W2104876248 hasPublicationYear "2008" @default.
- W2104876248 type Work @default.
- W2104876248 sameAs 2104876248 @default.
- W2104876248 citedByCount "190" @default.
- W2104876248 countsByYear W21048762482012 @default.
- W2104876248 countsByYear W21048762482013 @default.
- W2104876248 countsByYear W21048762482014 @default.
- W2104876248 countsByYear W21048762482015 @default.
- W2104876248 countsByYear W21048762482016 @default.