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• W2104876332 endingPage "3097" @default.
• W2104876332 startingPage "3087" @default.
• W2104876332 abstract "Natural selection is expected to act strongly on immune system genes as hosts adapt to novel, diverse, and coevolving pathogens. Population genetic studies of host defense genes with parallel functions in model organisms have revealed distinct evolutionary histories among the different components-receptors, adaptors, and effectors-of the innate immune system. In humans, however, detailed evolutionary studies have been mainly confined to the receptors and in particular to Toll-like receptors (TLRs). By virtue of a toll/interleukin-1 receptor (TIR) domain, TLRs activate distinct signaling pathways, which are mediated by the five TIR-containing adaptors: myeloid differentiation factor-88 (MyD88), myeloid differentiation factor-88 adaptor-like protein (MAL), toll/interleukin-1 receptor domain-containing adaptor protein inducing interferon (IFN)β (TRIF), toll/interleukin-1 receptor domain-containing adaptor protein inducing IFNβ-related adaptor molecule (TRAM), and sterile α- and armadillo motif-containing protein (SARM). Here, we have examined the extent to which natural selection has affected immune adaptors in humans, using as a paradigm the TIR-containing adaptors. To do so, we characterized their levels of naturally occurring genetic variation in various human populations. We found that MyD88 and TRIF have mainly evolved under purifying selection, suggesting that their role in the early stages of signal transduction is essential and nonredundant for host survival. In addition, the adaptors have been targeted by multiple episodes of positive selection, differing in timing and spatial location. MyD88 and SARM display signatures of a selective sweep that has occurred in all humans, whereas for the other three adaptors, we detected signatures of adaptive evolution that are restricted to specific populations. Our study provides evidence that the contemporary diversity of the five TIR-containing adaptors results from the intermingling of different selective events, swinging between constraint and adaptation." @default.
• W2104876332 created "2016-06-24" @default.
• W2104876332 creator A5012236358 @default.
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• W2104876332 creator A5052206379 @default.
• W2104876332 creator A5088435548 @default.
• W2104876332 date "2011-06-09" @default.
• W2104876332 modified "2023-10-17" @default.
• W2104876332 title "Evolution of the TIR Domain-Containing Adaptors in Humans: Swinging between Constraint and Adaptation" @default.
• W2104876332 cites W1525285200 @default.
• W2104876332 cites W1543052543 @default.
• W2104876332 cites W1575164178 @default.
• W2104876332 cites W1588312796 @default.
• W2104876332 cites W1919772617 @default.
• W2104876332 cites W1968666836 @default.
• W2104876332 cites W1971392091 @default.
• W2104876332 cites W1972673599 @default.
• W2104876332 cites W1976424894 @default.
• W2104876332 cites W1982603712 @default.
• W2104876332 cites W1984844169 @default.
• W2104876332 cites W1985753192 @default.
• W2104876332 cites W1987303272 @default.
• W2104876332 cites W1988178045 @default.
• W2104876332 cites W1992709102 @default.
• W2104876332 cites W1995744610 @default.
• W2104876332 cites W1998055077 @default.
• W2104876332 cites W1999988283 @default.
• W2104876332 cites W2003912358 @default.
• W2104876332 cites W2004465286 @default.
• W2104876332 cites W2005226427 @default.
• W2104876332 cites W2017742161 @default.
• W2104876332 cites W2024745007 @default.
• W2104876332 cites W2025253353 @default.
• W2104876332 cites W2027443452 @default.
• W2104876332 cites W2028704045 @default.
• W2104876332 cites W2034028219 @default.
• W2104876332 cites W2034533794 @default.
• W2104876332 cites W2034951669 @default.
• W2104876332 cites W2035454589 @default.
• W2104876332 cites W2039845199 @default.
• W2104876332 cites W2047865956 @default.
• W2104876332 cites W2052283409 @default.
• W2104876332 cites W2054159498 @default.
• W2104876332 cites W2055543630 @default.
• W2104876332 cites W2059145105 @default.
• W2104876332 cites W2059545122 @default.
• W2104876332 cites W2065152431 @default.
• W2104876332 cites W2067911388 @default.
• W2104876332 cites W2068851900 @default.
• W2104876332 cites W2071162967 @default.
• W2104876332 cites W2083878136 @default.
• W2104876332 cites W2084603524 @default.
• W2104876332 cites W2091903891 @default.
• W2104876332 cites W2092713838 @default.
• W2104876332 cites W2092768543 @default.
• W2104876332 cites W2094063883 @default.
• W2104876332 cites W2096420865 @default.
• W2104876332 cites W2100439192 @default.
• W2104876332 cites W2102234847 @default.
• W2104876332 cites W2102714321 @default.
• W2104876332 cites W2103844658 @default.
• W2104876332 cites W2107804596 @default.
• W2104876332 cites W2109130014 @default.
• W2104876332 cites W2110270701 @default.
• W2104876332 cites W2114858518 @default.
• W2104876332 cites W2115185894 @default.
• W2104876332 cites W2116382435 @default.
• W2104876332 cites W2119279196 @default.
• W2104876332 cites W2124285343 @default.
• W2104876332 cites W2126204254 @default.
• W2104876332 cites W2127178674 @default.
• W2104876332 cites W2132393729 @default.
• W2104876332 cites W2133449490 @default.
• W2104876332 cites W2135370544 @default.
• W2104876332 cites W2136091734 @default.
• W2104876332 cites W2137590150 @default.
• W2104876332 cites W2138049915 @default.
• W2104876332 cites W2140320046 @default.
• W2104876332 cites W2140784970 @default.
• W2104876332 cites W2141040025 @default.
• W2104876332 cites W2143092625 @default.
• W2104876332 cites W2149656250 @default.
• W2104876332 cites W2152217285 @default.
• W2104876332 cites W2157149092 @default.
• W2104876332 cites W2162530578 @default.
• W2104876332 cites W2163031152 @default.
• W2104876332 cites W2168619087 @default.
• W2104876332 cites W2169197527 @default.
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• W2104876332 doi "https://doi.org/10.1093/molbev/msr137" @default.
• W2104876332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21659570" @default.
• W2104876332 hasPublicationYear "2011" @default.
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