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• W2104880421 abstract "Previously it has been shown that persistent activation of the stimulatory adenylyl cyclase pathway with cholera toxin (CT) downregulates the Gsα polypeptide (80%) in a cAMP-independent manner in C6 glioma cells (Shah, 1997). This study was conducted to examine the short and long term effects of CT on the regulation of pertussis toxin-sensitive and -insensitive G proteins and their transcripts in C6 glioma cells. Treatment of C6 cells with CT (100 ng/ml) up to 16 h had no effect on either Gi or Gq/11α proteins. However, prolonged exposure (24-48 h) caused increased expression of Gi (20-30%) and Gq/11α proteins (40%). Urea gradient gels, which can separate Gqα and G11α proteins, revealed that prolonged CT treatment increased the expression of both of these G proteins. The CT-mediated enhanced expression of Gqα and G11α proteins was accompanied by increased mRNA levels of these proteins as determined by RT/PCR. Cyclic-AMP elevating agents like forskolin (10 µM) and db-cAMP (1 mM) mimicked the effect of CT on Gi but not Gq/11α proteins. These studies show long term cAMP-dependent regulation of Gi and cAMP-independent expression of Gq/11α proteins in C6 glioma cells." @default.
• W2104880421 created "2016-06-24" @default.
• W2104880421 creator A5005711988 @default.
• W2104880421 date "1999-06-01" @default.
• W2104880421 modified "2023-10-16" @default.
• W2104880421 title "Cholera toxin mediated regulation of the expression of Gqα and G11α GTP binding proteins" @default.
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• W2104880421 doi "https://doi.org/10.1038/emm.1999.15" @default.
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