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• W2104881191 abstract "Pharmacological screening and usage of natural products for the treatment of human diseases has had a long history from traditional medicine to modern drugs. The majority of modern drugs are reported to be mostly from natural products. The aim of the present study was to evaluate the inhibitory activity of 5-(2,4-dimethylbenzyl) pyrrolidin-2-one (DMBPO) extracted from marine Streptomyces VITSVK5 spp. isolated from sediment samples collected at Marakkanam coast of Bay of Bengal, India. The lead compound was isolated by bioactive guided extraction and purified by silica gel column chromatography. Structural elucidation of the lead compound was carried out by using UV, FT-IR, 1H NMR, 13C NMR, DEPT and HR-MS spectral data. Systematic screening of isolates for antimicrobial activity lead to identification of a potential strain, Streptomyces VITSVK5 spp. (GQ848482). Bioactivity guided extraction yielded a compound DMBPO and its inhibitory activity was tested against selected bacterial and fungal strains. DMBPO showed maximal activity against Escherichia coli with a MIC value of 187 μg/ml, followed by Klebsiella pneumoniae (MIC of 220 μg/ml and 10.3 mm zone of inhibition), Staphylococcus aureus (MIC of >1000 μg/ml and 4.4 mm zone of inhibition) and Bacillus subtilis (MIC of 850 μg/ml and 2.6 mm zone of inhibition). Furthermore, DMBPO was found to be a potent inhibitor of opportunistic fungal pathogens too. It showed a maximum activity against Aspergillus niger with a MIC value of 1 μg/ml and 28 mm zone of inhibition. The result of this study indicates that DMBPO possess antibiotic activity to selected bacterial and fungal pathogens and exhibited better activity against fungi than bacteria. Antecedentes: El cribado farmacológico y el uso de productos naturales para el tratamiento de las enfermedades humanas tiene un largo historial que comienza en la medicina tradicional y se extiende hasta los fármacos modernos. La mayoría de los fármacos modernos proceden principalmente de productos naturales. El objetivo del presente estudio fue valorar la actividad inhibidora of 5-(2,4-dimetilbencil) pirrolidin-2-uno (DMBPO) extraído de Streptomyces VITSVK5 sp. marino aislado de muestras de sedimento recolectadas en la costa de Marakkanam de la bahía de Bengala, India. El compuesto principal se aisló mediante extracción bioactiva guiada y se purificó mediante cromatografía de columna de gel de sílice. La dilucidación estructural del compuesto principal se efectuó utilizando datos espectrales de las técnicas UV, FT-IR, 1H NMR, 13C NMR, DEPT y HR-MS. El cribado sistemático de los aislamientos en busca de actividad antimicrobiana dio lugar a la identificación de una cepa potencial, Streptomyces VITSVK5 sp. (GQ848482). Con la extracción bioactiva guiada se obtuvo un compuesto DMBPO y su actividad inhibidora se examinó frente a cepas bacterianas y fúngicas seleccionadas. DMBPO mostró una actividad máxima frente a Escherichia coli con un valor de la concentración inhibitoria mínima (CIM) de 187 μg/ml, seguida de Klebsiella pneumoniae (CIM de 220 μg/ml y zona de inhibición de 10,3 mm), Staphylococcus aureus (CIM > 1.000 μg/ml y zona de inhibición de 4,4 mm) y Bacillus subtilis (CIM de 850 μg/ml y zona de inhibición de 2,6 mm). Además, se puso de relieve que DMBPO también fue un inhibidor potente de los patógenos fúngicos oportunistas. Se demostró una actividad máxima frente a Aspergillus niger con un valor de CIM de 1 μg/ml y una zona de inhibición de 28 mm. El resultado del presente estudio indica que DMBPO posee actividad antibiótica frente a patógenos bacterianos y fúngicos seleccionados y exhibió una mejor actividad frente a hongos que bacterias." @default.
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• W2104881191 date "2012-01-01" @default.
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• W2104881191 title "In vitro activity of 5-(2,4-dimethylbenzyl) pyrrolidin-2-one extracted from marine Streptomyces VITSVK5 spp. against fungal and bacterial human pathogens" @default.
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• W2104881191 doi "https://doi.org/10.1016/j.riam.2011.06.008" @default.
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