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- W2104881640 abstract "Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a maternally inherited mitochondrial syndrome characterized by seizures, migrainous headaches, lactic acidosis, vomiting, and recurrent stroke-like episodes. Patients often suffer from cognitive dysfunction of unclear pathogenesis. In this study, we explored a possible link between cognitive dysfunction and hippocampal expression of calbindin D28KD (CB), a high affinity calcium-binding protein, in four MELAS patients, using post mortem hippocampal tissues. We found significantly reduced CB levels in all patients by immunohistochemistry, Western blot, and quantitative real-time PCR. Reduction in CB expression has been associated with aging and with neurodegenerative disorders, including Alzheimer's disease. We postulate that the reduced CB expression may play a role in the cognitive abnormalities associated with MELAS." @default.
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- W2104881640 date "2012-06-01" @default.
- W2104881640 modified "2023-10-07" @default.
- W2104881640 title "Decreased hippocampal expression of calbindin D28K and cognitive impairment in MELAS" @default.
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- W2104881640 doi "https://doi.org/10.1016/j.jns.2012.03.005" @default.
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