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- W2104885668 abstract "Various lines of evidence suggest a respiratory route of transmission of nephropathia epidemica (NE). To study the response of the respiratory tract in NE, fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) was performed in 5 patients in the acute phase of the disease. Compared to a reference group of 15 healthy individuals, BAL fluid of NE patients contained significantly higher total numbers of cells (p <0.05) and significantly higher numbers of lysozyme-positive macrophages (p <0.01), CD8+ T cells (p <0.01), and natural killer (NK) cells (p < 0.01). There was no significant difference in numbers of CD4+ T cells, B cells, or neutrophils. When blood samples of 16 patients were examined at various intervals after onset of NE, a significant decrease in the number of NK cells (p < 0.01) was found in the acute phase of the disease. The findings are compatible with the presence of a local host response in the lower respiratory tract to NE virus infection." @default.
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- W2104885668 date "1993-01-01" @default.
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- W2104885668 title "Local Host Response in the Lower Respiratory Tract in Nephropathia Epidemica" @default.
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- W2104885668 doi "https://doi.org/10.3109/00365549309008554" @default.
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