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- W2104889905 abstract "Accurate gene prediction and automated annotation is lagging behind needs for the rapidly growing number of new genomes. Prediction tools are increasingly sophisticated and accurate. These draw on the range of available gene evidence and improved modeling of gene structures. Yet they are sensitive to available organism data and expected structures. Detection of novel and diverged genes remains problematic. Even for species clades with a well-characterized model such as Drosophila, gene finding is an uncertain task. Next generation genomics technology, such as genome-wide tile expression, finds thousands of genes have been missed by current methods. Combining Next-Gen genome data with prediction tools for both new and well-characterized Arthropod genomes uncovers 10% to 50% new species genes and diverged genes. We envision Genome Grid analysis pipelines that many scientists can use, installed on NSF TeraGrid and other shared cyberinfrastructure, as part of a Generic Model Organism Database project (GMOD, gmod.org/Genome_grid). Middleware and science gateway methods to use computational grids for genome analyses are in development as an open source project. Genome community software is now available, at TeraGrid tg_community/genomes, and for local use. These tools help genome analyses keep pace with rapid expansion of genomics information." @default.
- W2104889905 created "2016-06-24" @default.
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- W2104889905 date "2008-01-01" @default.
- W2104889905 modified "2023-09-27" @default.
- W2104889905 title "A Genome Grid for Finding new Bug Genes" @default.
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