Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104891965> ?p ?o ?g. }
- W2104891965 endingPage "886" @default.
- W2104891965 startingPage "875" @default.
- W2104891965 abstract "Vesicle-mediated protein transport between organelles of the secretory and endocytic pathways is strongly influenced by the composition and organization of membrane lipids. In budding yeast, protein transport between the trans-Golgi network (TGN) and early endosome (EE) requires Drs2, a phospholipid translocase in the type IV P-type ATPase family. However, downstream effectors of Drs2 and specific phospholipid substrate requirements for protein transport in this pathway are unknown. Here, we show that the Arf GTPase-activating protein (ArfGAP) Gcs1 is a Drs2 effector that requires a variant of the ArfGAP lipid packing sensor (+ALPS) motif for localization to TGN/EE membranes. Drs2 increases membrane curvature and anionic phospholipid composition of the cytosolic leaflet, both of which are sensed by the +ALPS motif. Using mutant forms of Drs2 and the related protein Dnf1, which alter their ability to recognize phosphatidylserine, we show that translocation of this substrate to the cytosolic leaflet is essential for +ALPS binding and vesicular transport between the EE and the TGN." @default.
- W2104891965 created "2016-06-24" @default.
- W2104891965 creator A5011925546 @default.
- W2104891965 creator A5013755274 @default.
- W2104891965 creator A5040847469 @default.
- W2104891965 creator A5047717868 @default.
- W2104891965 creator A5054105866 @default.
- W2104891965 date "2013-09-09" @default.
- W2104891965 modified "2023-10-14" @default.
- W2104891965 title "Phosphatidylserine flipping enhances membrane curvature and negative charge required for vesicular transport" @default.
- W2104891965 cites W1564648482 @default.
- W2104891965 cites W1844964971 @default.
- W2104891965 cites W1968842619 @default.
- W2104891965 cites W1971859508 @default.
- W2104891965 cites W1977203758 @default.
- W2104891965 cites W1981026057 @default.
- W2104891965 cites W1981635932 @default.
- W2104891965 cites W1984250381 @default.
- W2104891965 cites W1986194352 @default.
- W2104891965 cites W1989126866 @default.
- W2104891965 cites W1989479561 @default.
- W2104891965 cites W1994528127 @default.
- W2104891965 cites W1996841085 @default.
- W2104891965 cites W2002292732 @default.
- W2104891965 cites W2014069822 @default.
- W2104891965 cites W2022598996 @default.
- W2104891965 cites W2023226895 @default.
- W2104891965 cites W2032762300 @default.
- W2104891965 cites W2038591876 @default.
- W2104891965 cites W2046138985 @default.
- W2104891965 cites W2046189032 @default.
- W2104891965 cites W2052531986 @default.
- W2104891965 cites W2054342311 @default.
- W2104891965 cites W2054808321 @default.
- W2104891965 cites W2056485755 @default.
- W2104891965 cites W2057407467 @default.
- W2104891965 cites W2061539000 @default.
- W2104891965 cites W2070149348 @default.
- W2104891965 cites W2072167784 @default.
- W2104891965 cites W2078802378 @default.
- W2104891965 cites W2080627293 @default.
- W2104891965 cites W2094888005 @default.
- W2104891965 cites W2099133435 @default.
- W2104891965 cites W2099304106 @default.
- W2104891965 cites W2101934167 @default.
- W2104891965 cites W2105478531 @default.
- W2104891965 cites W2106333373 @default.
- W2104891965 cites W2114519069 @default.
- W2104891965 cites W2121868653 @default.
- W2104891965 cites W2125872855 @default.
- W2104891965 cites W2135585405 @default.
- W2104891965 cites W2138752468 @default.
- W2104891965 cites W2144036357 @default.
- W2104891965 cites W2155955312 @default.
- W2104891965 cites W2161438543 @default.
- W2104891965 cites W2165852907 @default.
- W2104891965 cites W2166600875 @default.
- W2104891965 cites W2166840071 @default.
- W2104891965 cites W4240065971 @default.
- W2104891965 doi "https://doi.org/10.1083/jcb.201305094" @default.
- W2104891965 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3776346" @default.
- W2104891965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24019533" @default.
- W2104891965 hasPublicationYear "2013" @default.
- W2104891965 type Work @default.
- W2104891965 sameAs 2104891965 @default.
- W2104891965 citedByCount "113" @default.
- W2104891965 countsByYear W21048919652013 @default.
- W2104891965 countsByYear W21048919652014 @default.
- W2104891965 countsByYear W21048919652015 @default.
- W2104891965 countsByYear W21048919652016 @default.
- W2104891965 countsByYear W21048919652017 @default.
- W2104891965 countsByYear W21048919652018 @default.
- W2104891965 countsByYear W21048919652019 @default.
- W2104891965 countsByYear W21048919652020 @default.
- W2104891965 countsByYear W21048919652021 @default.
- W2104891965 countsByYear W21048919652022 @default.
- W2104891965 countsByYear W21048919652023 @default.
- W2104891965 crossrefType "journal-article" @default.
- W2104891965 hasAuthorship W2104891965A5011925546 @default.
- W2104891965 hasAuthorship W2104891965A5013755274 @default.
- W2104891965 hasAuthorship W2104891965A5040847469 @default.
- W2104891965 hasAuthorship W2104891965A5047717868 @default.
- W2104891965 hasAuthorship W2104891965A5054105866 @default.
- W2104891965 hasBestOaLocation W21048919651 @default.
- W2104891965 hasConcept C119062480 @default.
- W2104891965 hasConcept C130316041 @default.
- W2104891965 hasConcept C144647389 @default.
- W2104891965 hasConcept C1491633281 @default.
- W2104891965 hasConcept C158617107 @default.
- W2104891965 hasConcept C163181125 @default.
- W2104891965 hasConcept C167019083 @default.
- W2104891965 hasConcept C207332259 @default.
- W2104891965 hasConcept C2777278457 @default.
- W2104891965 hasConcept C2778918659 @default.
- W2104891965 hasConcept C2779637612 @default.
- W2104891965 hasConcept C28005876 @default.
- W2104891965 hasConcept C41625074 @default.
- W2104891965 hasConcept C51785407 @default.