Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104892016> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2104892016 endingPage "172" @default.
- W2104892016 startingPage "162" @default.
- W2104892016 abstract "ara-Cytidine-5 9 -alkylphosphonophosphates and the corresponding -diphosphates were found to be cytostatically active in vitro against the human mammary epithelial cell line H184 A1N4 and the human mammary tumor cell line MaTu. Our results indicate that the replacement of the diphosphate by the phosphonophosphate group has no influence on anti- proliferative activity in this case. The compounds were more active than the corresponding cytidine phospholipid conju- gates and related compounds lacking a cytostatically active nucleoside, the ara-C prodrug Cytoros, and were slightly less active than ara-C. The cytostatic effect was prevented by 2 9 - deoxycytidine indicating their action as prodrugs of ara-C. In contrast to ara-C, they increase (Ca 2 1 ) 1 in H184 A1N4 cells, pointing to a different mechanism of action in addition to their prodrug effect. In combination with phospholipid ana- logs, synergistic effects could be observed. Further studies within the disease-oriented in vitro Anticancer Screening Pro- gram of the National Cancer Institute show selectivity for cer- tain cancer cell lines. The hexadecyl derivatives revealed a sig- nificant antitumor activity in vivo against the murine lymphatic leukemia P 388 cells being equally potent or even superior to ara-C. In contrast to ara-C, they were found to be orally active. Side effects measured as leukopenia and body weight reduction were less pronounced than with the parent drug. —Brachwitz, H., J. Bergmann, I. Fichtner, Y. Thomas, C. Vollgraf, P. Langen, and W. E. Berdel. 1- b - D -Arabinofuranosyl- cytosine-5 9 -alkylphosphonophosphates and diphosphates: new orally active derivatives of ara-C. J. Lipid Res. 1998. 39: 162-172." @default.
- W2104892016 created "2016-06-24" @default.
- W2104892016 creator A5015081490 @default.
- W2104892016 creator A5018224101 @default.
- W2104892016 creator A5021018039 @default.
- W2104892016 creator A5025105470 @default.
- W2104892016 creator A5032199613 @default.
- W2104892016 creator A5036497901 @default.
- W2104892016 creator A5074023473 @default.
- W2104892016 date "1998-01-01" @default.
- W2104892016 modified "2023-09-26" @default.
- W2104892016 title "1-β-d-Arabinofuranosylcytosine-5′-alkylphosphonophosphates and diphosphates: new orally active derivatives of ara-C" @default.
- W2104892016 cites W1798204859 @default.
- W2104892016 cites W1965379624 @default.
- W2104892016 cites W1970958639 @default.
- W2104892016 cites W1971969457 @default.
- W2104892016 cites W1981832105 @default.
- W2104892016 cites W1983600681 @default.
- W2104892016 cites W1991044267 @default.
- W2104892016 cites W1995204151 @default.
- W2104892016 cites W2010151367 @default.
- W2104892016 cites W2048118253 @default.
- W2104892016 cites W2057149365 @default.
- W2104892016 cites W2070011592 @default.
- W2104892016 cites W2074307831 @default.
- W2104892016 cites W2079260075 @default.
- W2104892016 cites W2089577605 @default.
- W2104892016 cites W2141260882 @default.
- W2104892016 cites W2145229153 @default.
- W2104892016 cites W2319619421 @default.
- W2104892016 cites W4236017207 @default.
- W2104892016 doi "https://doi.org/10.1016/s0022-2275(20)34212-7" @default.
- W2104892016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9469595" @default.
- W2104892016 hasPublicationYear "1998" @default.
- W2104892016 type Work @default.
- W2104892016 sameAs 2104892016 @default.
- W2104892016 citedByCount "10" @default.
- W2104892016 countsByYear W21048920162014 @default.
- W2104892016 countsByYear W21048920162015 @default.
- W2104892016 crossrefType "journal-article" @default.
- W2104892016 hasAuthorship W2104892016A5015081490 @default.
- W2104892016 hasAuthorship W2104892016A5018224101 @default.
- W2104892016 hasAuthorship W2104892016A5021018039 @default.
- W2104892016 hasAuthorship W2104892016A5025105470 @default.
- W2104892016 hasAuthorship W2104892016A5032199613 @default.
- W2104892016 hasAuthorship W2104892016A5036497901 @default.
- W2104892016 hasAuthorship W2104892016A5074023473 @default.
- W2104892016 hasBestOaLocation W21048920161 @default.
- W2104892016 hasConcept C185592680 @default.
- W2104892016 hasConcept C55493867 @default.
- W2104892016 hasConcept C71240020 @default.
- W2104892016 hasConcept C86803240 @default.
- W2104892016 hasConcept C98274493 @default.
- W2104892016 hasConceptScore W2104892016C185592680 @default.
- W2104892016 hasConceptScore W2104892016C55493867 @default.
- W2104892016 hasConceptScore W2104892016C71240020 @default.
- W2104892016 hasConceptScore W2104892016C86803240 @default.
- W2104892016 hasConceptScore W2104892016C98274493 @default.
- W2104892016 hasIssue "1" @default.
- W2104892016 hasLocation W21048920161 @default.
- W2104892016 hasLocation W21048920162 @default.
- W2104892016 hasOpenAccess W2104892016 @default.
- W2104892016 hasPrimaryLocation W21048920161 @default.
- W2104892016 hasRelatedWork W1531601525 @default.
- W2104892016 hasRelatedWork W1990781990 @default.
- W2104892016 hasRelatedWork W1996140555 @default.
- W2104892016 hasRelatedWork W2085061074 @default.
- W2104892016 hasRelatedWork W2606768298 @default.
- W2104892016 hasRelatedWork W2606769243 @default.
- W2104892016 hasRelatedWork W2748952813 @default.
- W2104892016 hasRelatedWork W2899084033 @default.
- W2104892016 hasRelatedWork W2948807893 @default.
- W2104892016 hasRelatedWork W2778153218 @default.
- W2104892016 hasVolume "39" @default.
- W2104892016 isParatext "false" @default.
- W2104892016 isRetracted "false" @default.
- W2104892016 magId "2104892016" @default.
- W2104892016 workType "article" @default.