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• W2104892859 abstract "Alcohol abuse and diseases related to alcohol use, when considered together, constitute the third largest health problem in the United States and affect more than 10 million Americans. Twenty-five percent to 30% of hospitalizations are related to alcohol abuse, and 200,000 deaths each year are caused by alcohol-related disease.15, 75 As shown in Table 1, alcoholic cirrhosis has the highest mortality rates among all the different types of cirrhosis.60 The role of liver biopsy in the evaluation of alcohol-related liver disease has been questioned by some who believe the information obtained from a biopsy may not add significantly to that available from clinical laboratory data and radiology findings.2, 68 Liver biopsy is relatively safe, however, with an associated morbidity of 0.1% to 0.6% and a mortality rate of 0.01% to 0.03%.30, 32, 57 There is also relatively small interobserver variation in the histologic interpretation of alcoholic liver disease (ALD), with greater agreement in samples containing more than six portal tracts.8 Liver biopsies are not routinely performed in the diagnosis and treatment of ALD, so the true incidence of the various histologic changes associated with alcohol use is difficult to determine because the group of patients who are biopsied are not randomly selected. If we set aside objections to the nonrandom nature of the population sampled, however, some interesting facts emerge. Biopsies of the livers of several groups of alcohol abusers showed no pathologic changes in 15% of the livers sampled, 40% of the biopsies showed simple fatty changes, 15% showed alcoholic hepatitis (AH), 10% demonstrated cirrhosis, and 20% had changes not related to alcohol abuse.5 Recent studies demonstrate a strong association between allelic polymorphisms within the tumor necrosis factor ∝ promoter region and the development of alcoholic steatohepatitis and cirrhosis in heavy drinkers.10, 33 This article reviews the major histopathologic features of alcohol-related liver disease and emphasizes the important prognostic features. These morphologic features of ALD may exist independently of each other and do not necessarily represent a continuum of changes (Fig. 1)." @default.
• W2104892859 created "2016-06-24" @default.
• W2104892859 creator A5055652702 @default.
• W2104892859 date "1998-11-01" @default.
• W2104892859 modified "2023-09-26" @default.
• W2104892859 title "HISTOPATHOLOGY OF ALCOHOLIC LIVER DISEASE" @default.
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• W2104892859 doi "https://doi.org/10.1016/s1089-3261(05)70040-4" @default.
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