Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104896067> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2104896067 abstract "We investigated transport systems for tri-iodothyronine (T(3)) and thyroxine (T(4)) in the human choriocarcinoma cell line, JAR, using a range of structurally similar compounds to determine whether these thyroid hormones are transported by common or different mechanisms. Saturable T(3) but not saturable T(4) uptake was inhibited by a wide range of aromatic compounds (nitrendipine, nifedipine, verapamil, meclofenamic acid, mefenamic acid, diazepam, phenytoin). Nitrendipine and diazepam were the most effective inhibitors of saturable thyroid hormone uptake. Nitrendipine decreased the K(m) for T(4) uptake from a control value of around 500 nM to around 300 nM (n=6). In contrast, the K(m) for T(3) uptake was increased from a control value of around 300 nM to around 750 nM (n=4). Diazepam had similar effects. This divergent shift in affinity for the uptake of T(3) and T(4) suggested that separate uptake systems exist for these two thyroid hormones. This provides evidence for at least two transporters mediating uptake of T(3) and T(4) in JAR cells: a specific T(4) transporter that does not interact with T(3) or structurally similar compounds; and a shared iodothyronine transporter that interacts with T(3), T(4), nitrendipine and diazepam." @default.
- W2104896067 created "2016-06-24" @default.
- W2104896067 creator A5010361938 @default.
- W2104896067 creator A5011851211 @default.
- W2104896067 creator A5043632764 @default.
- W2104896067 creator A5058423993 @default.
- W2104896067 date "2000-12-01" @default.
- W2104896067 modified "2023-09-28" @default.
- W2104896067 title "Different transporters for tri-iodothyronine (T(3)) and thyroxine (T(4)) in the human choriocarcinoma cell line, JAR" @default.
- W2104896067 cites W1748780063 @default.
- W2104896067 cites W1967092925 @default.
- W2104896067 cites W1971233187 @default.
- W2104896067 cites W1987855161 @default.
- W2104896067 cites W2000467504 @default.
- W2104896067 cites W2002663021 @default.
- W2104896067 cites W2005271651 @default.
- W2104896067 cites W2011409384 @default.
- W2104896067 cites W2042656992 @default.
- W2104896067 cites W2060645547 @default.
- W2104896067 cites W2063727293 @default.
- W2104896067 cites W2160428231 @default.
- W2104896067 cites W2205432407 @default.
- W2104896067 cites W2329856164 @default.
- W2104896067 cites W2441553178 @default.
- W2104896067 doi "https://doi.org/10.1677/joe.0.1670487" @default.
- W2104896067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11115776" @default.
- W2104896067 hasPublicationYear "2000" @default.
- W2104896067 type Work @default.
- W2104896067 sameAs 2104896067 @default.
- W2104896067 citedByCount "9" @default.
- W2104896067 countsByYear W21048960672013 @default.
- W2104896067 countsByYear W21048960672014 @default.
- W2104896067 countsByYear W21048960672015 @default.
- W2104896067 crossrefType "journal-article" @default.
- W2104896067 hasAuthorship W2104896067A5010361938 @default.
- W2104896067 hasAuthorship W2104896067A5011851211 @default.
- W2104896067 hasAuthorship W2104896067A5043632764 @default.
- W2104896067 hasAuthorship W2104896067A5058423993 @default.
- W2104896067 hasBestOaLocation W21048960671 @default.
- W2104896067 hasConcept C126322002 @default.
- W2104896067 hasConcept C134018914 @default.
- W2104896067 hasConcept C185592680 @default.
- W2104896067 hasConcept C2776175493 @default.
- W2104896067 hasConcept C2777022698 @default.
- W2104896067 hasConcept C2779066535 @default.
- W2104896067 hasConcept C2780548744 @default.
- W2104896067 hasConcept C519063684 @default.
- W2104896067 hasConcept C71315377 @default.
- W2104896067 hasConcept C71924100 @default.
- W2104896067 hasConcept C86803240 @default.
- W2104896067 hasConcept C98274493 @default.
- W2104896067 hasConceptScore W2104896067C126322002 @default.
- W2104896067 hasConceptScore W2104896067C134018914 @default.
- W2104896067 hasConceptScore W2104896067C185592680 @default.
- W2104896067 hasConceptScore W2104896067C2776175493 @default.
- W2104896067 hasConceptScore W2104896067C2777022698 @default.
- W2104896067 hasConceptScore W2104896067C2779066535 @default.
- W2104896067 hasConceptScore W2104896067C2780548744 @default.
- W2104896067 hasConceptScore W2104896067C519063684 @default.
- W2104896067 hasConceptScore W2104896067C71315377 @default.
- W2104896067 hasConceptScore W2104896067C71924100 @default.
- W2104896067 hasConceptScore W2104896067C86803240 @default.
- W2104896067 hasConceptScore W2104896067C98274493 @default.
- W2104896067 hasLocation W21048960671 @default.
- W2104896067 hasLocation W21048960672 @default.
- W2104896067 hasLocation W21048960673 @default.
- W2104896067 hasOpenAccess W2104896067 @default.
- W2104896067 hasPrimaryLocation W21048960671 @default.
- W2104896067 hasRelatedWork W1907386793 @default.
- W2104896067 hasRelatedWork W2052404366 @default.
- W2104896067 hasRelatedWork W2074542824 @default.
- W2104896067 hasRelatedWork W2106649546 @default.
- W2104896067 hasRelatedWork W2108671981 @default.
- W2104896067 hasRelatedWork W2120360050 @default.
- W2104896067 hasRelatedWork W2413643308 @default.
- W2104896067 isParatext "false" @default.
- W2104896067 isRetracted "false" @default.
- W2104896067 magId "2104896067" @default.
- W2104896067 workType "article" @default.