FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104903351> ?p ?o ?g. }

• W2104903351 endingPage "1402" @default.
• W2104903351 startingPage "1389" @default.
• W2104903351 abstract "ABSTRACT We have recently shown that the nuclear mitotic apparatus protein (NuMA) is composed of at least three isoforms that differ mainly at the carboxy terminus, and are generated by alternative splicing of a common mRNA precursor from a single NuMA gene (J. Cell Sci. (1993) 104, 249-260). Transient expression of human NuMA-l isoform (T33/p230) in Chinese hamster ovary polyoma (CHOP) cells showed that NuMA-l was present in interphase nuclei and was concentrated at the polar regions of the spindle apparatus in mitotic cells. However, expression of two other isoforms (NuMA-m and -s) revealed a distinct sub-cellular localization. NuMA-m (U4/p195) and NuMA-s (U6/p194) were present in the interphase cytosol and appeared to be mainly located at the centrosomal region. When cells entered into mitosis, however, NuMA-m and −s moved to the mitotic spindle pole. Analysis of a series of linker scanning-mutants and NuMA/β-galactosidase chimeric proteins showed that residues 1972-2007 of NuMA-l constitute a novel nuclear localization signal (NLS) and residues 1538-2115 are necessary and sufficient for spindle association. Further analysis of the NLS by site-specific mutagenesis indicated that Lys1988 is essential for nuclear targeting, whereas Arg1984 is not. These results have allowed us tentatively to assign specific biological activities to distinct structural domains of the NuMA polypeptide." @default.
• W2104903351 created "2016-06-24" @default.
• W2104903351 creator A5002768199 @default.
• W2104903351 creator A5075548524 @default.
• W2104903351 creator A5075816950 @default.
• W2104903351 date "1994-06-01" @default.
• W2104903351 modified "2023-10-11" @default.
• W2104903351 title "Nuclear mitotic apparatus protein (NuMA): spindle association, nuclear targeting and differential subcellular localization of various numa isoforms" @default.
• W2104903351 cites W1496379245 @default.
• W2104903351 cites W182940434 @default.
• W2104903351 cites W1872471228 @default.
• W2104903351 cites W1988093899 @default.
• W2104903351 cites W1993572893 @default.
• W2104903351 cites W2000146554 @default.
• W2104903351 cites W2001978323 @default.
• W2104903351 cites W2005617448 @default.
• W2104903351 cites W2006724602 @default.
• W2104903351 cites W2013446898 @default.
• W2104903351 cites W2019894624 @default.
• W2104903351 cites W2032920533 @default.
• W2104903351 cites W2033306271 @default.
• W2104903351 cites W2057653339 @default.
• W2104903351 cites W2060088582 @default.
• W2104903351 cites W2068513215 @default.
• W2104903351 cites W2080716529 @default.
• W2104903351 cites W2087656195 @default.
• W2104903351 cites W2089414651 @default.
• W2104903351 cites W2116940382 @default.
• W2104903351 cites W2126463247 @default.
• W2104903351 cites W2140047247 @default.
• W2104903351 cites W2143301797 @default.
• W2104903351 cites W2156297922 @default.
• W2104903351 cites W2410670802 @default.
• W2104903351 cites W2436951856 @default.
• W2104903351 cites W296632615 @default.
• W2104903351 cites W322972368 @default.
• W2104903351 cites W45974969 @default.
• W2104903351 doi "https://doi.org/10.1242/jcs.107.6.1389" @default.
• W2104903351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7962183" @default.
• W2104903351 hasPublicationYear "1994" @default.
• W2104903351 type Work @default.
• W2104903351 sameAs 2104903351 @default.
• W2104903351 citedByCount "56" @default.
• W2104903351 countsByYear W21049033512013 @default.
• W2104903351 countsByYear W21049033512014 @default.
• W2104903351 countsByYear W21049033512016 @default.
• W2104903351 countsByYear W21049033512017 @default.
• W2104903351 countsByYear W21049033512018 @default.
• W2104903351 countsByYear W21049033512019 @default.
• W2104903351 countsByYear W21049033512020 @default.
• W2104903351 countsByYear W21049033512021 @default.
• W2104903351 crossrefType "journal-article" @default.
• W2104903351 hasAuthorship W2104903351A5002768199 @default.
• W2104903351 hasAuthorship W2104903351A5075548524 @default.
• W2104903351 hasAuthorship W2104903351A5075816950 @default.
• W2104903351 hasConcept C104317684 @default.
• W2104903351 hasConcept C1491633281 @default.
• W2104903351 hasConcept C153911025 @default.
• W2104903351 hasConcept C190062978 @default.
• W2104903351 hasConcept C29452124 @default.
• W2104903351 hasConcept C29512474 @default.
• W2104903351 hasConcept C47432576 @default.
• W2104903351 hasConcept C49805395 @default.
• W2104903351 hasConcept C53345823 @default.
• W2104903351 hasConcept C54355233 @default.
• W2104903351 hasConcept C54458228 @default.
• W2104903351 hasConcept C67705224 @default.
• W2104903351 hasConcept C70547292 @default.
• W2104903351 hasConcept C85813293 @default.
• W2104903351 hasConcept C86339819 @default.
• W2104903351 hasConcept C86803240 @default.
• W2104903351 hasConcept C93304396 @default.
• W2104903351 hasConcept C95444343 @default.
• W2104903351 hasConceptScore W2104903351C104317684 @default.
• W2104903351 hasConceptScore W2104903351C1491633281 @default.
• W2104903351 hasConceptScore W2104903351C153911025 @default.
• W2104903351 hasConceptScore W2104903351C190062978 @default.
• W2104903351 hasConceptScore W2104903351C29452124 @default.
• W2104903351 hasConceptScore W2104903351C29512474 @default.
• W2104903351 hasConceptScore W2104903351C47432576 @default.
• W2104903351 hasConceptScore W2104903351C49805395 @default.
• W2104903351 hasConceptScore W2104903351C53345823 @default.
• W2104903351 hasConceptScore W2104903351C54355233 @default.
• W2104903351 hasConceptScore W2104903351C54458228 @default.
• W2104903351 hasConceptScore W2104903351C67705224 @default.
• W2104903351 hasConceptScore W2104903351C70547292 @default.
• W2104903351 hasConceptScore W2104903351C85813293 @default.
• W2104903351 hasConceptScore W2104903351C86339819 @default.
• W2104903351 hasConceptScore W2104903351C86803240 @default.
• W2104903351 hasConceptScore W2104903351C93304396 @default.
• W2104903351 hasConceptScore W2104903351C95444343 @default.
• W2104903351 hasIssue "6" @default.
• W2104903351 hasLocation W21049033511 @default.
• W2104903351 hasLocation W21049033512 @default.
• W2104903351 hasOpenAccess W2104903351 @default.
• W2104903351 hasPrimaryLocation W21049033511 @default.
• W2104903351 hasRelatedWork W2058289056 @default.
• W2104903351 hasRelatedWork W2096841518 @default.

• next