FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104927481> ?p ?o ?g. }

• W2104927481 endingPage "1078" @default.
• W2104927481 startingPage "1069" @default.
• W2104927481 abstract "Oxaliplatin is an anticancer drug routinely used to treat colorectal, gastroesophageal, ovarian, breast, head/neck, and genitourinary cancers. Discontinuation of oxaliplatin treatment is mostly because of peripheral neuropathy, more often than for tumor progression, potentially compromising patient benefit. Several strategies to prevent neurotoxicity have so far been investigated. To overcome this life-threatening side effect, while taking advantage of the antineoplastic activities of oxaliplatin, we describe in detail recent findings on the underlying mechanisms of genetic variants associated with toxicity and resistance to oxaliplatin-based chemotherapy in colorectal cancer. A comprehensive panel of eight polymorphisms, previously validated as significant markers related to oxaliplatin toxicity, is proposed and discussed. In addition, the most common available strategies or methods to prevent/minimize the toxicity were described in detail. Moreover, an early outline evaluation of the genotyping costs and methods was taken in consideration. With the availability of individual pharmacogenomic profiles, the oncologists will have new means to make treatment decisions for their patients that maximize benefit and minimize toxicity. With this purpose in mind, the clinician and lab manager should cooperate to evaluate the advantages and limitations, in terms of costs and applicability, of the most appropriate pharmacogenomic tests for routine incorporation into clinical practice." @default.
• W2104927481 created "2016-06-24" @default.
• W2104927481 creator A5005578190 @default.
• W2104927481 creator A5030795518 @default.
• W2104927481 creator A5033265900 @default.
• W2104927481 creator A5044888208 @default.
• W2104927481 creator A5049075689 @default.
• W2104927481 creator A5062904109 @default.
• W2104927481 creator A5066976468 @default.
• W2104927481 creator A5074752423 @default.
• W2104927481 creator A5077695264 @default.
• W2104927481 creator A5087488942 @default.
• W2104927481 date "2013-11-01" @default.
• W2104927481 modified "2023-10-01" @default.
• W2104927481 title "Current strategies to minimize toxicity of oxaliplatin" @default.
• W2104927481 cites W1972248724 @default.
• W2104927481 cites W2004858550 @default.
• W2104927481 cites W2006678622 @default.
• W2104927481 cites W2017806433 @default.
• W2104927481 cites W2063517047 @default.
• W2104927481 cites W2081400874 @default.
• W2104927481 cites W2087937897 @default.
• W2104927481 cites W2087960902 @default.
• W2104927481 cites W2102788703 @default.
• W2104927481 cites W2109420488 @default.
• W2104927481 cites W2127187776 @default.
• W2104927481 cites W2153906296 @default.
• W2104927481 cites W2160472801 @default.
• W2104927481 cites W2274215789 @default.
• W2104927481 cites W2397961238 @default.
• W2104927481 cites W60448409 @default.
• W2104927481 doi "https://doi.org/10.1097/cad.0000000000000002" @default.
• W2104927481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24025562" @default.
• W2104927481 hasPublicationYear "2013" @default.
• W2104927481 type Work @default.
• W2104927481 sameAs 2104927481 @default.
• W2104927481 citedByCount "33" @default.
• W2104927481 countsByYear W21049274812014 @default.
• W2104927481 countsByYear W21049274812015 @default.
• W2104927481 countsByYear W21049274812016 @default.
• W2104927481 countsByYear W21049274812017 @default.
• W2104927481 countsByYear W21049274812018 @default.
• W2104927481 countsByYear W21049274812019 @default.
• W2104927481 countsByYear W21049274812020 @default.
• W2104927481 countsByYear W21049274812021 @default.
• W2104927481 countsByYear W21049274812022 @default.
• W2104927481 countsByYear W21049274812023 @default.
• W2104927481 crossrefType "journal-article" @default.
• W2104927481 hasAuthorship W2104927481A5005578190 @default.
• W2104927481 hasAuthorship W2104927481A5030795518 @default.
• W2104927481 hasAuthorship W2104927481A5033265900 @default.
• W2104927481 hasAuthorship W2104927481A5044888208 @default.
• W2104927481 hasAuthorship W2104927481A5049075689 @default.
• W2104927481 hasAuthorship W2104927481A5062904109 @default.
• W2104927481 hasAuthorship W2104927481A5066976468 @default.
• W2104927481 hasAuthorship W2104927481A5074752423 @default.
• W2104927481 hasAuthorship W2104927481A5077695264 @default.
• W2104927481 hasAuthorship W2104927481A5087488942 @default.
• W2104927481 hasConcept C121608353 @default.
• W2104927481 hasConcept C126322002 @default.
• W2104927481 hasConcept C143998085 @default.
• W2104927481 hasConcept C170734499 @default.
• W2104927481 hasConcept C177713679 @default.
• W2104927481 hasConcept C2778715236 @default.
• W2104927481 hasConcept C2780962732 @default.
• W2104927481 hasConcept C29730261 @default.
• W2104927481 hasConcept C526805850 @default.
• W2104927481 hasConcept C60644358 @default.
• W2104927481 hasConcept C71924100 @default.
• W2104927481 hasConcept C86803240 @default.
• W2104927481 hasConcept C98274493 @default.
• W2104927481 hasConceptScore W2104927481C121608353 @default.
• W2104927481 hasConceptScore W2104927481C126322002 @default.
• W2104927481 hasConceptScore W2104927481C143998085 @default.
• W2104927481 hasConceptScore W2104927481C170734499 @default.
• W2104927481 hasConceptScore W2104927481C177713679 @default.
• W2104927481 hasConceptScore W2104927481C2778715236 @default.
• W2104927481 hasConceptScore W2104927481C2780962732 @default.
• W2104927481 hasConceptScore W2104927481C29730261 @default.
• W2104927481 hasConceptScore W2104927481C526805850 @default.
• W2104927481 hasConceptScore W2104927481C60644358 @default.
• W2104927481 hasConceptScore W2104927481C71924100 @default.
• W2104927481 hasConceptScore W2104927481C86803240 @default.
• W2104927481 hasConceptScore W2104927481C98274493 @default.
• W2104927481 hasIssue "10" @default.
• W2104927481 hasLocation W21049274811 @default.
• W2104927481 hasLocation W21049274812 @default.
• W2104927481 hasOpenAccess W2104927481 @default.
• W2104927481 hasPrimaryLocation W21049274811 @default.
• W2104927481 hasRelatedWork W2029040122 @default.
• W2104927481 hasRelatedWork W2051936046 @default.
• W2104927481 hasRelatedWork W2098707609 @default.
• W2104927481 hasRelatedWork W2465617904 @default.
• W2104927481 hasRelatedWork W2577979650 @default.
• W2104927481 hasRelatedWork W2587456836 @default.
• W2104927481 hasRelatedWork W2766974801 @default.
• W2104927481 hasRelatedWork W2954397477 @default.
• W2104927481 hasRelatedWork W3025153715 @default.

• next