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- W2104928343 endingPage "167" @default.
- W2104928343 startingPage "155" @default.
- W2104928343 abstract "Cachexia represents progressive wasting of muscle and adipose tissue and is associated with increased morbidity and mortality. Although anorexia usually accompanies cachexia, cachexia rarely responds to increased food intake alone. Our knowledge of the underlying mechanisms responsible for cachexia remains incomplete. However, most states of cachexia are associated with underlying inflammatory processes and/or cancer. These processes activate protein degradation and lipolytic pathways, resulting in tissue loss. In this article, we briefly review the pathophysiology of cachexia and discuss the role of specific nutrient supplements for the treatment of cachexia. The branched chain amino acid leucine, the leucine metaboliteβ ‐hydroxy‐β‐methylbutyrate, arginine, glutamine, ω‐3 long chain fatty acids, conjugated linoleic acid, and polyphenols have demonstrated some efficacy in animal and/or human studies. Optimal treatment for cachexia is likely aimed at maximizing muscle and adipose synthesis while minimizing degradation." @default.
- W2104928343 created "2016-06-24" @default.
- W2104928343 creator A5011026923 @default.
- W2104928343 creator A5018437086 @default.
- W2104928343 creator A5023265907 @default.
- W2104928343 creator A5084350144 @default.
- W2104928343 date "2006-04-01" @default.
- W2104928343 modified "2023-09-23" @default.
- W2104928343 title "Nutrition Modulation of Cachexia/Proteolysis" @default.
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