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• W2104939091 abstract "Tumor cells can co-opt the promigratory activity of chemokines and their cognate G protein-coupled receptors (GPCRs) to metastasize to regional lymph nodes or distant organs. Indeed, the migration toward SDF-1 (stromal cell-derived factor 1) of tumor cells bearing CXCR4 [chemokine (C-X-C motif) receptor 4] has been implicated in the lymphatic and organ-specific metastasis of various human malignancies. Here, we used chimeric G proteins and GPCRs activated solely by artificial ligands to selectively activate the signaling pathways downstream of specific G proteins and showed that CXCR4-mediated chemotaxis and transendothelial migration of metastatic basal-like breast cancer cells required activation of Gα(13), a member of the Gα(12/13) G protein family, and of the small guanosine triphosphatase Rho. Multiple complementary experimental strategies, including synthetic biology approaches, indicated that signaling-selective inhibition of the CXCR4-Gα(13)-Rho axis prevents the metastatic spread of basal-like breast cancer cells." @default.
• W2104939091 created "2016-06-24" @default.
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• W2104939091 date "2011-09-20" @default.
• W2104939091 modified "2023-10-03" @default.
• W2104939091 title "A Synthetic Biology Approach Reveals a CXCR4-G₁₃-Rho Signaling Axis Driving Transendothelial Migration of Metastatic Breast Cancer Cells" @default.
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• W2104939091 doi "https://doi.org/10.1126/scisignal.2002221" @default.
• W2104939091 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3429372" @default.
• W2104939091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21934106" @default.
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