Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104958604> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2104958604 abstract "Often, interesting candidate tumor markers are not only genes that show homogeneously higher expression (HHE) in tumor samples compared to control samples, but also genes with only predominantly higher expression (PHE), i.e. genes which exhibit higher expression in at least 80 per cent of tumor samples. Standard parametric test statistics used in the analysis of microarray experiments may fail with PHE as a consequence of the mixture of distributions present in the tumor group. As alternative we consider trimmed t-statistics which compare group mean values after removing outliers in each group. The trimming proportion can be chosen adaptively, either based on a boxplot outlier detection rule or by optimization over a series of tests with varying trimming proportions. The trimmed t-statistics can be plugged into the 'significance analysis of microarrays' (SAM) procedure, yielding the modified boxplot rule test (modBox) and the modified optimization test (modOpt), respectively. By means of simulation of microarray experiments, we show that modOpt is superior to contenders in detecting PHE, while there is only little loss in efficiency under HHE compared to SAM. Analysis of a real microarray experiment revealed that, out of nearly 29 000 genes, about 417 genes exhibiting PHE are detected by modOpt but missed by SAM." @default.
- W2104958604 created "2016-06-24" @default.
- W2104958604 creator A5019700420 @default.
- W2104958604 creator A5033707884 @default.
- W2104958604 creator A5040146633 @default.
- W2104958604 creator A5071157720 @default.
- W2104958604 creator A5086495385 @default.
- W2104958604 date "2010-10-20" @default.
- W2104958604 modified "2023-09-26" @default.
- W2104958604 title "Adaptive trimmed t-statistics for identifying predominantly high expression in a microarray experiment" @default.
- W2104958604 cites W1979505860 @default.
- W2104958604 cites W1986397115 @default.
- W2104958604 cites W2007929673 @default.
- W2104958604 cites W2024128221 @default.
- W2104958604 cites W2054541484 @default.
- W2104958604 cites W2079484991 @default.
- W2104958604 cites W2083675953 @default.
- W2104958604 cites W2084491844 @default.
- W2104958604 cites W2086402713 @default.
- W2104958604 cites W2095967516 @default.
- W2104958604 cites W2111799408 @default.
- W2104958604 cites W2121158863 @default.
- W2104958604 cites W2132029495 @default.
- W2104958604 cites W2158017189 @default.
- W2104958604 cites W2167382937 @default.
- W2104958604 cites W2170214198 @default.
- W2104958604 cites W2260541909 @default.
- W2104958604 cites W4294107304 @default.
- W2104958604 doi "https://doi.org/10.1002/sim.4093" @default.
- W2104958604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20963766" @default.
- W2104958604 hasPublicationYear "2010" @default.
- W2104958604 type Work @default.
- W2104958604 sameAs 2104958604 @default.
- W2104958604 citedByCount "8" @default.
- W2104958604 countsByYear W21049586042012 @default.
- W2104958604 countsByYear W21049586042013 @default.
- W2104958604 countsByYear W21049586042014 @default.
- W2104958604 countsByYear W21049586042019 @default.
- W2104958604 countsByYear W21049586042021 @default.
- W2104958604 crossrefType "journal-article" @default.
- W2104958604 hasAuthorship W2104958604A5019700420 @default.
- W2104958604 hasAuthorship W2104958604A5033707884 @default.
- W2104958604 hasAuthorship W2104958604A5040146633 @default.
- W2104958604 hasAuthorship W2104958604A5071157720 @default.
- W2104958604 hasAuthorship W2104958604A5086495385 @default.
- W2104958604 hasConcept C104317684 @default.
- W2104958604 hasConcept C105795698 @default.
- W2104958604 hasConcept C111919701 @default.
- W2104958604 hasConcept C116714509 @default.
- W2104958604 hasConcept C150194340 @default.
- W2104958604 hasConcept C185429906 @default.
- W2104958604 hasConcept C186836561 @default.
- W2104958604 hasConcept C33923547 @default.
- W2104958604 hasConcept C41008148 @default.
- W2104958604 hasConcept C54355233 @default.
- W2104958604 hasConcept C56951928 @default.
- W2104958604 hasConcept C70721500 @default.
- W2104958604 hasConcept C79337645 @default.
- W2104958604 hasConcept C8415881 @default.
- W2104958604 hasConcept C86803240 @default.
- W2104958604 hasConcept C87007009 @default.
- W2104958604 hasConcept C95371953 @default.
- W2104958604 hasConceptScore W2104958604C104317684 @default.
- W2104958604 hasConceptScore W2104958604C105795698 @default.
- W2104958604 hasConceptScore W2104958604C111919701 @default.
- W2104958604 hasConceptScore W2104958604C116714509 @default.
- W2104958604 hasConceptScore W2104958604C150194340 @default.
- W2104958604 hasConceptScore W2104958604C185429906 @default.
- W2104958604 hasConceptScore W2104958604C186836561 @default.
- W2104958604 hasConceptScore W2104958604C33923547 @default.
- W2104958604 hasConceptScore W2104958604C41008148 @default.
- W2104958604 hasConceptScore W2104958604C54355233 @default.
- W2104958604 hasConceptScore W2104958604C56951928 @default.
- W2104958604 hasConceptScore W2104958604C70721500 @default.
- W2104958604 hasConceptScore W2104958604C79337645 @default.
- W2104958604 hasConceptScore W2104958604C8415881 @default.
- W2104958604 hasConceptScore W2104958604C86803240 @default.
- W2104958604 hasConceptScore W2104958604C87007009 @default.
- W2104958604 hasConceptScore W2104958604C95371953 @default.
- W2104958604 hasLocation W21049586041 @default.
- W2104958604 hasLocation W21049586042 @default.
- W2104958604 hasOpenAccess W2104958604 @default.
- W2104958604 hasPrimaryLocation W21049586041 @default.
- W2104958604 hasRelatedWork W1974599192 @default.
- W2104958604 hasRelatedWork W2006024165 @default.
- W2104958604 hasRelatedWork W2050744550 @default.
- W2104958604 hasRelatedWork W2089859276 @default.
- W2104958604 hasRelatedWork W2104958604 @default.
- W2104958604 hasRelatedWork W2375593830 @default.
- W2104958604 hasRelatedWork W2900947575 @default.
- W2104958604 hasRelatedWork W2998765584 @default.
- W2104958604 hasRelatedWork W3141198878 @default.
- W2104958604 hasRelatedWork W74695042 @default.
- W2104958604 isParatext "false" @default.
- W2104958604 isRetracted "false" @default.
- W2104958604 magId "2104958604" @default.
- W2104958604 workType "article" @default.