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- W2104984927 abstract "Summary: The mK3, K3, and K5 gene products from the γ2 group of γ‐herpesviruses are the founding members of a family of membrane‐associated ubiquitin E3 ligases. As part of the viral immunoevasion strategy, expression of these proteins results in a decrease in cell‐surface major histocompatibility complex class I molecules and other immunoreceptors including intercellular adhesion molecule‐1, CD86, and CD1d. These viral gene products all possess a characteristic cytosolic N‐terminal RING‐CH domain, responsible for ubiquitination of the target protein, and two membrane‐spanning segments required for substrate specificity. For the majority of substrates, ubiquitination at the cell surface leads to rapid internalization and endolysosomal degradation, while mK3 ubiquitinates class I molecules associated with the peptide‐loading complex resulting in proteasome‐mediated degradation. Related viral genes with similar functions have been found in poxviruses, suggesting appropriation of these genes from the eukaryotic host. Ten membrane‐associated RING‐CH (MARCH) human genes with a similar organization have now been identified, and their overexpression leads to ubiquitination and downregulation of a variety of cell‐surface immunoreceptors. While all the MARCH proteins are predicted to act as ubiquitin E3 ligases, their physiological role and substrates remain to be defined." @default.
- W2104984927 created "2016-06-24" @default.
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- W2104984927 creator A5075336505 @default.
- W2104984927 creator A5091310776 @default.
- W2104984927 creator A5091621309 @default.
- W2104984927 date "2005-09-23" @default.
- W2104984927 modified "2023-10-16" @default.
- W2104984927 title "Downregulation of cell surface receptors by the K3 family of viral and cellular ubiquitin E3 ligases" @default.
- W2104984927 cites W1556265700 @default.
- W2104984927 cites W1619304391 @default.
- W2104984927 cites W1832030339 @default.
- W2104984927 cites W1965969172 @default.
- W2104984927 cites W1966452733 @default.
- W2104984927 cites W1978662565 @default.
- W2104984927 cites W1978706791 @default.
- W2104984927 cites W1982961071 @default.
- W2104984927 cites W1986627314 @default.
- W2104984927 cites W1986986406 @default.
- W2104984927 cites W1988617344 @default.
- W2104984927 cites W1989862537 @default.
- W2104984927 cites W1994433593 @default.
- W2104984927 cites W1994939674 @default.
- W2104984927 cites W1998535540 @default.
- W2104984927 cites W2000441615 @default.
- W2104984927 cites W2003417921 @default.
- W2104984927 cites W2005175785 @default.
- W2104984927 cites W2009745195 @default.
- W2104984927 cites W2010617137 @default.
- W2104984927 cites W2017954030 @default.
- W2104984927 cites W2019987740 @default.
- W2104984927 cites W2024812887 @default.
- W2104984927 cites W2025226894 @default.
- W2104984927 cites W2027587005 @default.
- W2104984927 cites W2029119458 @default.
- W2104984927 cites W2029287748 @default.
- W2104984927 cites W2031108838 @default.
- W2104984927 cites W2032818498 @default.
- W2104984927 cites W2033313049 @default.
- W2104984927 cites W2033352476 @default.
- W2104984927 cites W2036925007 @default.
- W2104984927 cites W2037155908 @default.
- W2104984927 cites W2045298605 @default.
- W2104984927 cites W2057623594 @default.
- W2104984927 cites W2057668553 @default.
- W2104984927 cites W2057936860 @default.
- W2104984927 cites W2065446100 @default.
- W2104984927 cites W2065452543 @default.
- W2104984927 cites W2068650008 @default.
- W2104984927 cites W2069624186 @default.
- W2104984927 cites W2074876842 @default.
- W2104984927 cites W2077301497 @default.
- W2104984927 cites W2080553628 @default.
- W2104984927 cites W2081237630 @default.
- W2104984927 cites W2081376834 @default.
- W2104984927 cites W2083516848 @default.
- W2104984927 cites W2083892257 @default.
- W2104984927 cites W2084310601 @default.
- W2104984927 cites W2088619528 @default.
- W2104984927 cites W2091467720 @default.
- W2104984927 cites W2096216895 @default.
- W2104984927 cites W2104176887 @default.
- W2104984927 cites W2111368862 @default.
- W2104984927 cites W2114050199 @default.
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- W2104984927 cites W2117313136 @default.
- W2104984927 cites W2117927576 @default.
- W2104984927 cites W2123546970 @default.
- W2104984927 cites W2124670069 @default.
- W2104984927 cites W2133987610 @default.
- W2104984927 cites W2135374303 @default.
- W2104984927 cites W2140921627 @default.
- W2104984927 cites W2142107992 @default.
- W2104984927 cites W2144720739 @default.
- W2104984927 cites W2146183177 @default.
- W2104984927 cites W2149368193 @default.
- W2104984927 cites W2149616074 @default.
- W2104984927 cites W2166440816 @default.
- W2104984927 cites W2166712828 @default.
- W2104984927 cites W2166823732 @default.
- W2104984927 cites W2167663744 @default.
- W2104984927 cites W2169080894 @default.
- W2104984927 cites W4249939424 @default.
- W2104984927 doi "https://doi.org/10.1111/j.0105-2896.2005.00314.x" @default.
- W2104984927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16181331" @default.
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