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• W2105003802 abstract "<h3>Objective</h3> To evaluate the effects of topical ketorolac in patients undergoing vitreoretinal surgery. <h3>Methods</h3> One hundred nine patients undergoing vitrectomies were randomized to receive either topical ketorolac tromethamine, 0.4%, or placebo. Patients were instructed to begin taking the study medication 3 days preoperatively (4 times daily) and to continue taking it 4 weeks postoperatively. <h3>Main Outcome Measures</h3> Intraoperative pupil diameter, postoperative day 1 pain and inflammation, 1-month postoperative retinal thickness, and preoperative and 1-month postoperative best-corrected visual acuities. <h3>Results</h3> The difference in mean pupil diameters between patients using ketorolac and those taking placebo was 0.06 mm (<i>P</i> = .39). Patients taking ketorolac and those taking placebo had mean pain scores (scale, 1-10) of 0.24 (SD, 0.6) and 1.06 (SD, 2) (<i>P</i> = .03) and mean inflammation grades (grade, 0-4) of 0.59 (SD, 0.7) and 1.16 (SD, 0.9) (<i>P</i> < .001), respectively. Ketorolac reduced central subfield thickness by 8%, but this was not statistically significant. At 1 month, mean visual acuities improved to 0.40 logMAR units (mean Snellen, 20/50; SD, 0.28 logMAR units) in the ketorolac group from 0.83 logMAR units (20/150⁺²; SD, 0.60 logMAR units) at baseline and to 0.67 logMAR units (20/100⁺¹; SD, 0.46 logMAR units) in the placebo group from 0.92 logMAR units (20/150⁻²; SD, 0.62 logMAR units) at baseline (<i>P</i> = .001). <h3>Conclusions</h3> Topical ketorolac was well tolerated and safe, reduced postoperative pain and inflammation, and improved visual recovery in this prospective, double-masked trial. <h3>Application to Clinical Practice</h3> Topical ketorolac may benefit patients undergoing vitreoretinal surgery. <h3>Trial Registration</h3> clinicaltrials.gov Identifier:NCT00576329" @default.
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• W2105003802 date "2008-09-08" @default.
• W2105003802 modified "2023-10-17" @default.
• W2105003802 title "Topical Ketorolac in Vitreoretinal Surgery" @default.
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• W2105003802 doi "https://doi.org/10.1001/archopht.126.9.1203" @default.
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