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- W2105024630 abstract "Vascular dementia (VaD), like Alzheimer's disease (AD), is associated with cholinergic deficits. Rivastigmine provides sustained, brain-selective inhibition of acetylcholinesterase and butyrylcholinesterase. Preliminary data suggest that rivastigmine may provide significant benefits in patients with AD and cerebrovascular disease (mixed dementia), and in patients with VaD. Open-label rivastigmine treatment has been associated with improved cognitive and functional abilities, behavioral symptoms, and reduced caregiver stress in a small pilot study in these patients. Larger, prospective, double-blind studies of rivastigmine in patients with VaD are under way. These studies will confirm whether rivastigmine is an efficacious treatment option for a range of patients for whom, until now, there have been few symptomatic therapies." @default.
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- W2105024630 date "2003-07-01" @default.
- W2105024630 modified "2023-09-25" @default.
- W2105024630 title "Rivastigmine in Vascular Dementia" @default.
- W2105024630 doi "https://doi.org/10.1017/s1041610203009207" @default.
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