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• W2105039072 abstract "SUMMARY Haemocytes from the gastropod snail Lymnaea stagnalis (Linnaeus)were used as a model to characterize protein kinase C (PKC) signalling events in molluscan defence cells. Challenge of freshly collected haemocytes with theβ-1, 3-glucan laminarin resulted in a transient increase in the phosphorylation of haemocyte PKC, with maximal phosphorylation (represented by a 3.5-fold increase) occurring at 10 min; this effect was blocked by the PKC inhibitor, GF109203X. Moreover, extracellular signal-regulated kinase (ERK)was found to be a downstream target of molluscan PKC, operating via a MAPK/ERK kinase (MEK)-dependent mechanism. Pharmacological inhibition of PKC phosphorylation by U-73122 and ET-18-OCH3 suggested that laminarin-dependent PKC signalling was modulated via phospholipase C(PLC); however, a role for phosphatidylinositol-3-kinase (PI-3-K) is unlikely since the PI-3-K inhibitor LY294002 was without effect. Generation of H2O2 by haemocytes in response to laminarin was also investigated. H2O2 output increased in a dose- and time-dependent manner, with 10 mg ml-1 laminarin eliciting a 9.5-fold increase in H2O2 production after 30 min. H2O2 production was significantly attenuated by the PKC inhibitors, GF109203X and Gö 6976, and by the NADPH-oxidase inhibitor,apocynin. In conclusion, these data further our understanding of PKC signalling events in molluscan haemocytes and for the first time define a role for PKC in H2O2 production by these defence cells. Given that H2O2 is an important anti-pathogen molecule, and that haemocytes play a crucial role in the elimination of invading organisms,PKC signalling in these cells is likely to be crucial to the molluscan innate defence response." @default.
• W2105039072 created "2016-06-24" @default.
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• W2105039072 date "2006-12-15" @default.
• W2105039072 modified "2023-09-27" @default.
• W2105039072 title "β-1, 3-glucan modulates PKC signalling in<i>Lymnaea stagnalis</i>defence cells: a role for PKC in H2O2 production and downstream ERK activation" @default.
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• W2105039072 doi "https://doi.org/10.1242/jeb.02561" @default.
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