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- W2105050768 abstract "The transepithelial migration of Escherichia coli that expressed all possible combinations of a plasmid-encoded gonococcal porin (Por), opacity-associated protein (Opa), and 3F11 lipo-oligosaccharide (LOS) epitope was investigated. Surface expression of Por mediated selective changes in E. coli antibiotic susceptibility, and coexpression of Opa and the 3F11 LOS epitope mediated bacterial clumping (P<.01). In the human fallopian tube organ-culture model, Opa-producing variants attached up to 44-fold better than control bacteria (P<.01), and Por-producing variants exceeded submucosal invasion of control bacteria by 500-fold (P<.01). Opa and Por each facilitated intracellular invasion 20–40-fold (P<.01). In dual expresser variants, the 3F11 LOS epitope markedly reduced attachment and invasion mediated by Opa or Por. The LOS inhibitory effect was curbed when all 3 factors were expressed, which suggests an additional interaction of the 3 factors at the bacterial surface. Por, Opa, and LOS play important roles in Neisseria gonorrhoeae trafficking across human fallopian tube epithelium" @default.
- W2105050768 created "2016-06-24" @default.
- W2105050768 creator A5008527592 @default.
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- W2105050768 date "2001-08-15" @default.
- W2105050768 modified "2023-09-27" @default.
- W2105050768 title "Invasion of Human Fallopian Tube Epithelium by<i>Escherichia coli</i>Expressing Combinations of a Gonococcal Porin, Opacity‐Associated Protein, and Chimeric Lipo‐oligosaccharide" @default.
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- W2105050768 doi "https://doi.org/10.1086/322784" @default.
- W2105050768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11471104" @default.
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