FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105055165> ?p ?o ?g. }

• W2105055165 endingPage "2368" @default.
• W2105055165 startingPage "2359" @default.
• W2105055165 abstract "We recently demonstrated that reducing IGF-1 receptor (IGF-1R) numbers in the endothelium enhances nitric oxide (NO) bioavailability and endothelial cell insulin sensitivity. In the present report, we aimed to examine the effect of increasing IGF-1R on endothelial cell function and repair. To examine the effect of increasing IGF-1R in the endothelium, we generated mice overexpressing human IGF-1R in the endothelium (human IGF-1R endothelium-overexpressing mice [hIGFREO]) under direction of the Tie2 promoter enhancer. hIGFREO aorta had reduced basal NO bioavailability (percent constriction to NG-monomethyl-l-arginine [mean (SEM) wild type 106% (30%); hIGFREO 48% (10%)]; P &lt; 0.05). Endothelial cells from hIGFREO had reduced insulin-stimulated endothelial NO synthase activation (mean [SEM] wild type 170% [25%], hIGFREO 58% [3%]; P = 0.04) and insulin-stimulated NO release (mean [SEM] wild type 4,500 AU [1,000], hIGFREO 1,500 AU [700]; P &lt; 0.05). hIGFREO mice had enhanced endothelium regeneration after denuding arterial injury (mean [SEM] percent recovered area, wild type 57% [2%], hIGFREO 47% [5%]; P &lt; 0.05) and enhanced endothelial cell migration in vitro. The IGF-1R, although reducing NO bioavailability, enhances in situ endothelium regeneration. Manipulating IGF-1R in the endothelium may be a useful strategy to treat disorders of vascular growth and repair." @default.
• W2105055165 created "2016-06-24" @default.
• W2105055165 creator A5000195279 @default.
• W2105055165 creator A5005835656 @default.
• W2105055165 creator A5009806544 @default.
• W2105055165 creator A5013828318 @default.
• W2105055165 creator A5019280990 @default.
• W2105055165 creator A5025155035 @default.
• W2105055165 creator A5027312074 @default.
• W2105055165 creator A5037365059 @default.
• W2105055165 creator A5037520367 @default.
• W2105055165 creator A5046161371 @default.
• W2105055165 creator A5047452105 @default.
• W2105055165 creator A5051315610 @default.
• W2105055165 creator A5059776805 @default.
• W2105055165 creator A5077354357 @default.
• W2105055165 creator A5079099986 @default.
• W2105055165 creator A5079640562 @default.
• W2105055165 creator A5083588098 @default.
• W2105055165 creator A5086346331 @default.
• W2105055165 creator A5088046924 @default.
• W2105055165 date "2012-08-17" @default.
• W2105055165 modified "2023-10-16" @default.
• W2105055165 title "Novel Role of the IGF-1 Receptor in Endothelial Function and Repair" @default.
• W2105055165 cites W1603429689 @default.
• W2105055165 cites W1678800844 @default.
• W2105055165 cites W1978030502 @default.
• W2105055165 cites W1996148311 @default.
• W2105055165 cites W2002290804 @default.
• W2105055165 cites W2007275305 @default.
• W2105055165 cites W2009013636 @default.
• W2105055165 cites W2027784532 @default.
• W2105055165 cites W2031198359 @default.
• W2105055165 cites W2042203837 @default.
• W2105055165 cites W2045545124 @default.
• W2105055165 cites W2051269098 @default.
• W2105055165 cites W2087477127 @default.
• W2105055165 cites W2094110443 @default.
• W2105055165 cites W2096020435 @default.
• W2105055165 cites W2101305821 @default.
• W2105055165 cites W2107029521 @default.
• W2105055165 cites W2107287484 @default.
• W2105055165 cites W2107948591 @default.
• W2105055165 cites W2110424396 @default.
• W2105055165 cites W2120953129 @default.
• W2105055165 cites W2124521298 @default.
• W2105055165 cites W2128533010 @default.
• W2105055165 cites W2129753448 @default.
• W2105055165 cites W2129840397 @default.
• W2105055165 cites W2132693703 @default.
• W2105055165 cites W2141244124 @default.
• W2105055165 cites W2145765684 @default.
• W2105055165 cites W2146077146 @default.
• W2105055165 cites W2150429576 @default.
• W2105055165 cites W2151076854 @default.
• W2105055165 cites W2168898170 @default.
• W2105055165 cites W2171614223 @default.
• W2105055165 cites W2271022958 @default.
• W2105055165 doi "https://doi.org/10.2337/db11-1494" @default.
• W2105055165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3425420" @default.
• W2105055165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22733797" @default.
• W2105055165 hasPublicationYear "2012" @default.
• W2105055165 type Work @default.
• W2105055165 sameAs 2105055165 @default.
• W2105055165 citedByCount "56" @default.
• W2105055165 countsByYear W21050551652012 @default.
• W2105055165 countsByYear W21050551652013 @default.
• W2105055165 countsByYear W21050551652014 @default.
• W2105055165 countsByYear W21050551652015 @default.
• W2105055165 countsByYear W21050551652016 @default.
• W2105055165 countsByYear W21050551652017 @default.
• W2105055165 countsByYear W21050551652018 @default.
• W2105055165 countsByYear W21050551652019 @default.
• W2105055165 countsByYear W21050551652020 @default.
• W2105055165 countsByYear W21050551652021 @default.
• W2105055165 countsByYear W21050551652022 @default.
• W2105055165 countsByYear W21050551652023 @default.
• W2105055165 crossrefType "journal-article" @default.
• W2105055165 hasAuthorship W2105055165A5000195279 @default.
• W2105055165 hasAuthorship W2105055165A5005835656 @default.
• W2105055165 hasAuthorship W2105055165A5009806544 @default.
• W2105055165 hasAuthorship W2105055165A5013828318 @default.
• W2105055165 hasAuthorship W2105055165A5019280990 @default.
• W2105055165 hasAuthorship W2105055165A5025155035 @default.
• W2105055165 hasAuthorship W2105055165A5027312074 @default.
• W2105055165 hasAuthorship W2105055165A5037365059 @default.
• W2105055165 hasAuthorship W2105055165A5037520367 @default.
• W2105055165 hasAuthorship W2105055165A5046161371 @default.
• W2105055165 hasAuthorship W2105055165A5047452105 @default.
• W2105055165 hasAuthorship W2105055165A5051315610 @default.
• W2105055165 hasAuthorship W2105055165A5059776805 @default.
• W2105055165 hasAuthorship W2105055165A5077354357 @default.
• W2105055165 hasAuthorship W2105055165A5079099986 @default.
• W2105055165 hasAuthorship W2105055165A5079640562 @default.
• W2105055165 hasAuthorship W2105055165A5083588098 @default.
• W2105055165 hasAuthorship W2105055165A5086346331 @default.
• W2105055165 hasAuthorship W2105055165A5088046924 @default.
• W2105055165 hasBestOaLocation W21050551651 @default.

• next