FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105055259> ?p ?o ?g. }

• W2105055259 endingPage "888" @default.
• W2105055259 startingPage "882" @default.
• W2105055259 abstract "Patients with high risk prostate cancer (prostate specific antigen greater than 20 ng/ml, Gleason score greater than 7, or clinical stage T2b or greater) have been shown to have a 30% to 40% biochemical recurrence rate after definitive local therapy. Looking for improvement on these outcomes, we conducted a phase II clinical trial examining the combination of ketoconazole and docetaxel in the neoadjuvant setting before radical prostatectomy.A total of 22 patients with clinically localized, high risk prostate cancer were enrolled in the study. For 12 weeks they were treated with neoadjuvant docetaxel and ketoconazole, with dosing based on phase I data. Patients were monitored for tolerance of therapy and dosing adjustments were made for significant toxicities. Radical prostatectomy with extended lymph node dissection was subsequently performed and patients were followed postoperatively for biochemical recurrence.At a median followup of 18 months 8 patients remained biochemically free of recurrence after surgery alone. An additional 6 patients received salvage therapy and had an undetectable prostate specific antigen. Of the 22 patients 16 experienced National Cancer Institute grade 3 or 4 toxicity at some point during the therapy. However, 16 patients completed all 4 cycles of chemotherapy.Neoadjuvant ketoconazole combined with docetaxel has appreciable but acceptable toxicity with 73% of the patients completing all 4 courses of therapy. Of those who underwent radical prostatectomy 36% remained continuously biochemically free of recurrence at a median followup of 18 months." @default.
• W2105055259 created "2016-06-24" @default.
• W2105055259 creator A5010547832 @default.
• W2105055259 creator A5021405854 @default.
• W2105055259 creator A5054199952 @default.
• W2105055259 creator A5060965139 @default.
• W2105055259 creator A5077312194 @default.
• W2105055259 creator A5090369191 @default.
• W2105055259 date "2011-09-01" @default.
• W2105055259 modified "2023-10-13" @default.
• W2105055259 title "A Phase II Clinical Trial of Neoadjuvant Ketoconazole and Docetaxel Chemotherapy Before Radical Prostatectomy in High Risk Patients" @default.
• W2105055259 cites W1960373985 @default.
• W2105055259 cites W1963569255 @default.
• W2105055259 cites W1967324977 @default.
• W2105055259 cites W1968310949 @default.
• W2105055259 cites W1970316517 @default.
• W2105055259 cites W1973315097 @default.
• W2105055259 cites W1978267162 @default.
• W2105055259 cites W1981497922 @default.
• W2105055259 cites W1984369681 @default.
• W2105055259 cites W1985143599 @default.
• W2105055259 cites W1995110604 @default.
• W2105055259 cites W2058158189 @default.
• W2105055259 cites W2067475417 @default.
• W2105055259 cites W2080439368 @default.
• W2105055259 cites W2094315815 @default.
• W2105055259 cites W2097120102 @default.
• W2105055259 cites W2106493686 @default.
• W2105055259 cites W2117792530 @default.
• W2105055259 cites W2120292596 @default.
• W2105055259 cites W2140023635 @default.
• W2105055259 cites W2150909545 @default.
• W2105055259 cites W2163120057 @default.
• W2105055259 cites W2316095838 @default.
• W2105055259 cites W2403157107 @default.
• W2105055259 cites W2409202552 @default.
• W2105055259 doi "https://doi.org/10.1016/j.juro.2011.04.087" @default.
• W2105055259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21791342" @default.
• W2105055259 hasPublicationYear "2011" @default.
• W2105055259 type Work @default.
• W2105055259 sameAs 2105055259 @default.
• W2105055259 citedByCount "26" @default.
• W2105055259 countsByYear W21050552592012 @default.
• W2105055259 countsByYear W21050552592013 @default.
• W2105055259 countsByYear W21050552592014 @default.
• W2105055259 countsByYear W21050552592015 @default.
• W2105055259 countsByYear W21050552592016 @default.
• W2105055259 countsByYear W21050552592017 @default.
• W2105055259 countsByYear W21050552592018 @default.
• W2105055259 countsByYear W21050552592020 @default.
• W2105055259 countsByYear W21050552592021 @default.
• W2105055259 crossrefType "journal-article" @default.
• W2105055259 hasAuthorship W2105055259A5010547832 @default.
• W2105055259 hasAuthorship W2105055259A5021405854 @default.
• W2105055259 hasAuthorship W2105055259A5054199952 @default.
• W2105055259 hasAuthorship W2105055259A5060965139 @default.
• W2105055259 hasAuthorship W2105055259A5077312194 @default.
• W2105055259 hasAuthorship W2105055259A5090369191 @default.
• W2105055259 hasConcept C121608353 @default.
• W2105055259 hasConcept C126322002 @default.
• W2105055259 hasConcept C126894567 @default.
• W2105055259 hasConcept C141071460 @default.
• W2105055259 hasConcept C143998085 @default.
• W2105055259 hasConcept C16005928 @default.
• W2105055259 hasConcept C2776694085 @default.
• W2105055259 hasConcept C2778292576 @default.
• W2105055259 hasConcept C2779466945 @default.
• W2105055259 hasConcept C2779548794 @default.
• W2105055259 hasConcept C2780192828 @default.
• W2105055259 hasConcept C2780775027 @default.
• W2105055259 hasConcept C2781064554 @default.
• W2105055259 hasConcept C2781190966 @default.
• W2105055259 hasConcept C2781406297 @default.
• W2105055259 hasConcept C530470458 @default.
• W2105055259 hasConcept C71924100 @default.
• W2105055259 hasConceptScore W2105055259C121608353 @default.
• W2105055259 hasConceptScore W2105055259C126322002 @default.
• W2105055259 hasConceptScore W2105055259C126894567 @default.
• W2105055259 hasConceptScore W2105055259C141071460 @default.
• W2105055259 hasConceptScore W2105055259C143998085 @default.
• W2105055259 hasConceptScore W2105055259C16005928 @default.
• W2105055259 hasConceptScore W2105055259C2776694085 @default.
• W2105055259 hasConceptScore W2105055259C2778292576 @default.
• W2105055259 hasConceptScore W2105055259C2779466945 @default.
• W2105055259 hasConceptScore W2105055259C2779548794 @default.
• W2105055259 hasConceptScore W2105055259C2780192828 @default.
• W2105055259 hasConceptScore W2105055259C2780775027 @default.
• W2105055259 hasConceptScore W2105055259C2781064554 @default.
• W2105055259 hasConceptScore W2105055259C2781190966 @default.
• W2105055259 hasConceptScore W2105055259C2781406297 @default.
• W2105055259 hasConceptScore W2105055259C530470458 @default.
• W2105055259 hasConceptScore W2105055259C71924100 @default.
• W2105055259 hasIssue "3" @default.
• W2105055259 hasLocation W21050552591 @default.
• W2105055259 hasLocation W21050552592 @default.
• W2105055259 hasOpenAccess W2105055259 @default.
• W2105055259 hasPrimaryLocation W21050552591 @default.
• W2105055259 hasRelatedWork W1986124281 @default.

• next