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• W2105059079 abstract "Background The aim of this study was to evaluate how tissue gas tensions and tissue metabolites measured in situ can detect hypoperfusion and differentiate between aerobic and anaerobic conditions during hemorrhagic shock. We hypothesized that tissue PCO 2 ( PtCO 2 ) would detect hypoperfusion also under aerobic conditions and detect anaerobic metabolism concomitantly with or earlier than other markers. Methods Prospective experimental animal study with eight anesthetized pigs subjected to a continuous blood loss ∼ 8% of total blood volume per hour until death. We measured cardiac index, organ blood flows, and tissue levels of PO 2 , PCO 2 , glucose, pyruvate, lactate, and glycerol in intestine, liver, kidney, and skeletal muscle. Results With reduction in blood flow to the organs under aerobic conditions, PtCO 2 increased ∼ 1–4 kPa from baseline. With the onset of tissue hypoxia there was a pronounced increase of PtCO 2 , lactate, lactate‐pyruvate ( LP ) ratio, and glycerol. Tissue pH and bicarbonate decreased significantly, indicating that metabolic acid was buffered by bicarbonate to generate CO 2 . Conclusion Moderate tissue hypoperfusion under aerobic conditions is associated with increased PtCO 2 , in contrast to metabolic parameters of ischemia (lactate, LP ratio, and glycerol) which remain low. From the onset of ischemia there is a much more rapid and pronounced increase in PtCO 2 , lactate, and LP ratio. PtCO 2 can be used as a marker of hypoperfusion under both aerobic and anaerobic conditions; it gives an earlier warning of hypoperfusion than metabolic markers and increases concomitantly with or earlier than other markers at the onset of tissue anaerobiosis." @default.
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• W2105059079 date "2011-11-21" @default.
• W2105059079 modified "2023-10-09" @default.
• W2105059079 title "Tissue gas tensions and tissue metabolites for detection of organ hypoperfusion and ischemia" @default.
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• W2105059079 doi "https://doi.org/10.1111/j.1399-6576.2011.02572.x" @default.
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